1. Gene
  2. HOMER3 - homer scaffold protein 3 Gene

HOMER3 - homer scaffold protein 3 Gene

Homo sapiens

Also known as VESL3; HOMER-3

Gene ID: 9454 | Gene type: protein coding

About HOMER3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,929,201-18,941,217 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in spleen (RPKM 29.6), kidney (RPKM 6.7) and 19 other tissues.

Summary

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I Metabotropic Glutamate Receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as Neuronal Signaling, T-cell activation and trafficking of amyloid beta Peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

HOMER3 Products(4)

mRNA Protein Name
NM_001145721.1 NP_001139193.1 homer protein homolog 3 isoform 2
NM_001145722.2 NP_001139194.1 homer protein homolog 3 isoform 1
NM_001145724.1 NP_001139196.1 homer protein homolog 3 isoform 3
NM_004838.4 NP_004829.3 homer protein homolog 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
18218901 GOA
involved in negative regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
18218901 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOMER3 Protein Structure

WH1

WH1: WH1 domain (6 - 109)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

homer protein homolog 3

Homer, neuronal immediate early gene, 3

HOMER3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HOMER3 Q9NSC5 RUNX1T1 Homo sapiens Q06455-4
Y2H Array
25416956
Intra HOMER3 Q9NSC5 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra HOMER3 Q9NSC5 SLAIN1 Homo sapiens Q8ND83
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 SLAIN1 Homo sapiens Q8ND83
Y2H Array
32296183
Intra HOMER3 Q9NSC5 FRYL Homo sapiens O94915
Y2H Pooling
16189514
Intra HOMER3 Q9NSC5 FRYL Homo sapiens O94915
Anti Tag CoIP
33961781
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9-2
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9-2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra HOMER3 Q9NSC5 MSS51 Homo sapiens Q4VC12
Y2H Array
32296183
Intra HOMER3 Q9NSC5 MSS51 Homo sapiens Q4VC12
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 FAT1 Homo sapiens Q14517
ELISA
16979624
Intra HOMER3 Q9NSC5 FAT1 Homo sapiens Q14517
Imaging
16979624
Intra HOMER3 Q9NSC5 FAT1 Homo sapiens Q14517
Pull Down
16979624
Intra HOMER3 Q9NSC5 ABI1 Homo sapiens Q8IZP0-5
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 ABI1 Homo sapiens Q8IZP0-5
Y2H Array
32296183
Intra HOMER3 Q9NSC5 PSORS1C2 Homo sapiens Q9UIG4
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 FRYL Homo sapiens O94915-2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 FRYL Homo sapiens O94915-2
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 LHX2 Homo sapiens P50458
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 LHX2 Homo sapiens P50458
Y2H Array
32296183
Intra HOMER3 Q9NSC5 PALLD Homo sapiens Q8WX93-2
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 PALLD Homo sapiens Q8WX93-2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 TOX2 Homo sapiens Q96NM4-3
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 TOX2 Homo sapiens Q96NM4-3
Y2H Array
32296183
Intra HOMER3 Q9NSC5 PAX7 Homo sapiens P23759-2
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 PAX7 Homo sapiens P23759-2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 ZNF19 Homo sapiens P17023
Y2H Array
32296183
Intra HOMER3 Q9NSC5 ZNF19 Homo sapiens P17023
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 MOS Homo sapiens P00540
Validated Y2H
25416956
Intra HOMER3 Q9NSC5 MOS Homo sapiens P00540
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 LSM14B Homo sapiens Q9BX40-2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 LSM14B Homo sapiens Q9BX40-2
Y2H Prey Pooling
32296183
Cross HOMER3 Q9NSC5 yscB Yersinia pestis Q56973
Y2H Array
21911467
Cross HOMER3 Q9NSC5 a0a3n4b5w9_yerpe Yersinia pestis A0A3N4B5W9
Y2H Array
21911467
Intra HOMER3 Q9NSC5 MIA3 Homo sapiens Q5JRA6
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 MIA3 Homo sapiens Q5JRA6
Y2H Array
32296183
Intra HOMER3 Q9NSC5 SARG Homo sapiens Q9BW04
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 SARG Homo sapiens Q9BW04
Y2H Array
32296183
Intra HOMER3 Q9NSC5 PPP1R18 Homo sapiens Q6NYC8
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 PPP1R18 Homo sapiens Q6NYC8
Y2H Array
25416956
Intra HOMER3 Q9NSC5 ZBTB4 Homo sapiens Q9P1Z0
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 RBM22 Homo sapiens Q9NW64
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra HOMER3 Q9NSC5 NEBL Homo sapiens O76041
Validated Y2H
25416956
Intra HOMER3 Q9NSC5 APP Homo sapiens P05067-8
Anti Bait CoIP
18387811
Intra HOMER3 Q9NSC5 WIPF1 Homo sapiens O43516
Validated Y2H
25416956
Intra HOMER3 Q9NSC5 WIPF1 Homo sapiens O43516
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra HOMER3 Q9NSC5 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 EIF3D Homo sapiens O15371
Validated Y2H
25416956
Intra HOMER3 Q9NSC5 EIF3D Homo sapiens O15371
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 SNRPF Homo sapiens P62306
Validated Y2H
25416956
Intra HOMER3 Q9NSC5 SNRPF Homo sapiens P62306
Y2H Array
25416956
Intra HOMER3 Q9NSC5 SNRPF Homo sapiens P62306
Y2H Array
32296183
Intra HOMER3 Q9NSC5 SNRPF Homo sapiens P62306
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 SNRPF Homo sapiens P62306
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra HOMER3 Q9NSC5 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 SAXO1 Homo sapiens Q8IYX7
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 PKN1 Homo sapiens Q16512
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 PKN1 Homo sapiens Q16512
Y2H
21516116
Intra HOMER3 Q9NSC5 PKN1 Homo sapiens Q16512
Y2H Array
25416956
Intra HOMER3 Q9NSC5 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra HOMER3 Q9NSC5 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra HOMER3 Q9NSC5 C4orf17 Homo sapiens Q53FE4
Y2H Array
32296183
Intra HOMER3 Q9NSC5 WBP2 Homo sapiens Q969T9
Y2H Array
32296183
Intra HOMER3 Q9NSC5 WBP2 Homo sapiens Q969T9
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra HOMER3 Q9NSC5 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 FBXO28 Homo sapiens Q9NVF7
Y2H Array
32296183
Intra HOMER3 Q9NSC5 FBXO28 Homo sapiens Q9NVF7
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 POLI Homo sapiens Q9UNA4
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 ABI3 Homo sapiens Q9P2A4
Y2H Array
19060904
Intra HOMER3 Q9NSC5 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 ABI3 Homo sapiens Q9P2A4
Complementation
32296183
Intra HOMER3 Q9NSC5 ABI3 Homo sapiens Q9P2A4
Y2H Pooling
19060904
Intra HOMER3 Q9NSC5 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 DYNLL2 Homo sapiens Q96FJ2
Y2H Pooling
16189514
Intra HOMER3 Q9NSC5 DYNLL2 Homo sapiens Q96FJ2
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9
Y2H Prey Pooling
25416956
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra HOMER3 Q9NSC5 ABI2 Homo sapiens Q9NYB9
Anti Tag CoIP
33961781
Intra HOMER3 Q9NSC5 HOMER1 Homo sapiens Q86YM7
Y2H Array
32296183
Intra HOMER3 Q9NSC5 HOMER1 Homo sapiens Q86YM7
MAPPIT
32296183
Intra HOMER3 Q9NSC5 HOMER1 Homo sapiens Q86YM7
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 HOMER1 Homo sapiens Q86YM7
Anti Tag CoIP
33961781
Intra HOMER3 Q9NSC5 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 PAX6 Homo sapiens P26367
Y2H
16098226
Intra HOMER3 Q9NSC5 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra HOMER3 Q9NSC5 EAF1 Homo sapiens Q96JC9
Y2H
21516116
Intra HOMER3 Q9NSC5 EAF1 Homo sapiens Q96JC9
Validated Y2H
25416956
Intra HOMER3 Q9NSC5 EAF1 Homo sapiens Q96JC9
Y2H Array
25416956
Intra HOMER3 Q9NSC5 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra HOMER3 Q9NSC5 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra HOMER3 Q9NSC5 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra HOMER3 Q9NSC5 KANK4 Homo sapiens Q5T7N3
Y2H Array
32296183
Intra HOMER3 Q9NSC5 KANK4 Homo sapiens Q5T7N3
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 68

DFNA68

Autosomal Dominant Nonsyndromic Deafness 68

Autosomal Dominant Deafness 68

Deafness, Autosomal Dominant, 68

Spinocerebellar Ataxia, Autosomal Recessive 13

Autosomal Recessive Spinocerebellar Ataxia 13

SCAR13

Autosomal Recessive Congenital Cerebellar Ataxia Due To Mglur1 Deficiency

Autosomal Recessive Congenital Cerebellar Ataxia Due To Metabotropic Glutamate Receptor 1 Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 13

Spinocerebellar Ataxia, Autosomal Recessive, 13

Ataxia, Spinocerebellar, Autosomal Recessive, Type 13

Schizophrenia 6

SCZD6

Schizophrenia Susceptibility Locus, Chromosome 8p-Related

Schizophrenia, Type 6

Migraine, Familial Hemiplegic, 1

FHM1

Mhp1

Fhm

Familial Hemiplegic Migraine 1

Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia

Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia

Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia

Migraine, Hemiplegic, Familial, Type 1

Hemiplegic Migraine, Familial Type 1

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus HOMER3 MGD MGI:1347359
Canis familiaris HOMER3 VGNC VGNC:41738
Macaca mulatta HOMER3 VGNC VGNC:97774
Bos taurus HOMER3 VGNC VGNC:29903
Rattus norvegicus HOMER3 RGD RGD:620706
Felis catus HOMER3 VGNC VGNC:101460