CNST - consortin, connexin sorting protein Gene

Homo sapiens

Also known as C1orf71; PPP1R64

Gene ID: 163882 | Gene type: protein coding

About CNST

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:246,566,456-246,668,595 (from NCBI)

This gene has 4 transcripts (splice variants) and 237 orthologues. Ubiquitous expression in adrenal (RPKM 10.5), brain (RPKM 9.5) and 25 other tissues.

Summary

Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]

CNST Products(2)

mRNA	Protein	Name
NM_001139459.2	NP_001132931.1	consortin isoform 2
NM_152609.3	NP_689822.2	consortin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IDA IDA: Inferred from direct assay	19389623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19389623	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of Golgi to plasma membrane protein transport	IMP IMP: Inferred from mutant phenotype	19864490	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19864490	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19864490	GOA
located in transport vesicle	IDA IDA: Inferred from direct assay	19864490	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNST Protein Structure

Consortin_C

0
200
400
600
725 a.a.

Protein Preferred Names

Protein Names

consortin

protein phosphatase 1, regulatory subunit 64

CNST Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNST	Q6PJW8	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	25416956
Intra	CNST	Q6PJW8	ROPN1	Homo sapiens	Q9HAT0	Y2H Prey Pooling	25416956
Intra	CNST	Q6PJW8	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	25416956
Intra	CNST	Q6PJW8	PPP1CA	Homo sapiens	P62136	Y2H	22321011
Intra	CNST	Q6PJW8	PPP1CA	Homo sapiens	P62136	Far-WB	19389623
Intra	CNST	Q6PJW8	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Thyroid Dyshormonogenesis 4

Deiodinase Deficiency	TDH4
Iodotyrosine Dehalogenase Deficiency	Thyroid Hormonogenesis, Genetic Defect In, 4
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4	Genetic Defect In Thyroid Hormonogenesis 4
Chdh4	Congenital Hypothyroidism Due To Dyshormonogenesis Type 4
Genetic Defect In Thyroid Hormonogenesis Type 4

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02921	CNST Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CNST	VGNC	VGNC:61034
Bos taurus	CNST	VGNC	VGNC:27532
Canis familiaris	CNST	VGNC	VGNC:39428
Mus musculus	CNST	MGD	MGI:2445141
Macaca mulatta	CNST	VGNC	VGNC:71355
Rattus norvegicus	CNST	RGD	RGD:1564833

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