LONRF2 - LON peptidase N-terminal domain and ring finger 2 Gene

Homo sapiens

Also known as RNF192

Gene ID: 164832 | Gene type: protein coding

About LONRF2

This gene has 2 transcripts (splice variants), 204 orthologues and 2 paralogues. Biased expression in adrenal (RPKM 18.3), brain (RPKM 16.1) and 10 other tissues.

Summary

Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]

LONRF2 Products(2)

mRNA	Protein	Name
NM_001371783.1	NP_001358712.1	LON peptidase N-terminal domain and RING finger protein 2 isoform 2
NM_198461.4	NP_940863.3	LON peptidase N-terminal domain and RING finger protein 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LONRF2 Protein Structure

TPR_11

zf-RING_2

LON_substr_bdg

0
200
400
600
754 a.a.

Protein Preferred Names

Protein Names

LON peptidase N-terminal domain and RING finger protein 2

RING finger protein 192

LONRF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LONRF2	Q1L5Z9	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	LONRF2	Q1L5Z9	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	LONRF2	Q1L5Z9	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	LONRF2	Q1L5Z9	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	LONRF2	Q1L5Z9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	LONRF2	Q1L5Z9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	LONRF2	Q1L5Z9	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	LONRF2	Q1L5Z9	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	LONRF2	Q1L5Z9	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	LONRF2	Q1L5Z9	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	LONRF2	Q1L5Z9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	LONRF2	Q1L5Z9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	LONRF2	Q1L5Z9	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	LONRF2	Q1L5Z9	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	LONRF2	Q1L5Z9	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	LONRF2	Q1L5Z9	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	LONRF2	Q1L5Z9	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	LONRF2	Q1L5Z9	GFAP	Homo sapiens	P14136	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 15b

IMD15B

Immunodeficiency, Type 15b

Childhood Germ Cell Cancer

Pediatric Germ Cell Tumor	Paediatric Germ Cell Cancer
Paediatric Germ Cell Neoplasm	Pediatric Germ Cell Cancer
Pediatric Germ Cell Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07736	LONRF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LONRF2	RGD	RGD:1562137
Macaca mulatta	LONRF2	VGNC	VGNC:74348
Mus musculus	LONRF2	MGD	MGI:1920209
Canis familiaris	LONRF2	VGNC	VGNC:42735
Felis catus	LONRF2	VGNC	VGNC:63257
Others	LONRF2	NCBI

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