DDX1 - DEAD-box helicase 1 Gene

Homo sapiens

Also known as DBP-RB; UKVH5d

Gene ID: 1653 | Gene type: protein coding

About DDX1

Cytogenetic location: 2p24.3 Genomic coordinates (GRCh38): 2:15,591,868-15,631,101 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 36.4), brain (RPKM 36.1) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that acts as an ATP-dependent RNA helicase that has been found to promote coronaviruses replication. [provided by RefSeq, Aug 2021]

DDX1 Products(1)

mRNA	Protein	Name
NM_004939.3	NP_004930.1	ATP-dependent RNA helicase DDX1

DDX1 Protein Structure

DEAD

SPRY

Helicase_C

0
200
400
600
740 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DDX1

DEAD (Asp-Glu-Ala-Asp) box helicase 1

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Bronchitis

Chronic Bronchitis	Acute Bronchitis
Bronchitis, Chronic	Acute Bronchitis And Bronchiolitis
Chest Cold	Chest Infection
Ci - Chest Infection	Recurrent Wheezy Bronchitis
Bronchitis Chronic	Lower Respiratory Tract Infection
Acute Lower Respiratory Tract Infection	Chronic Bronchitis Nos
Senile Bronchitis	Bronchitis Nos In Those Under L5 Years Of Age
Bronchitis Nos

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Heavy Chain Disease

Hcd

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Lacrimal Duct Obstruction

Blocked Lacrimal Canaliculus	Obstruction Of Lacrimal Canaliculus
Obstruction Of Lacrimal Ducts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03629	DDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DDX1	RGD	RGD:619903
Macaca mulatta	DDX1	VGNC	VGNC:71759
Mus musculus	DDX1	MGD	MGI:2144727
Canis familiaris	DDX1	VGNC	VGNC:39844
Bos taurus	DDX1	VGNC	VGNC:27955
Felis catus	DDX1	VGNC	VGNC:61396
Others	DDX1	NCBI

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