RTRAF - RNA transcription, translation and transport factor Gene

Homo sapiens

Also known as CLE; CLE7; hCLE; CGI99; RLLM1; hCLE1; CGI-99; LCRP369; C14orf166

Gene ID: 51637 | Gene type: protein coding

About RTRAF

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,989,546-52,010,694 (from NCBI)

This gene has 7 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in testis (RPKM 109.7), fat (RPKM 62.2) and 25 other tissues.

Summary

Enables RNA binding activity; RNA polymerase II complex binding activity; and identical protein binding activity. Involved in negative regulation of protein kinase activity; positive regulation of transcription by RNA polymerase II; and tRNA splicing, via endonucleolytic cleavage and ligation. Located in microtubule cytoskeleton; nucleoplasm; and perinuclear region of cytoplasm. Part of tRNA-splicing Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

RTRAF Products(1)

mRNA	Protein	Name
NM_016039.3	NP_057123.1	RNA transcription, translation and transport factor protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	24608264	GOA
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	16950395	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15147888	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11507205	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	15147888	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16950395	GOA
involved in tRNA splicing, via endonucleolytic cleavage and ligation	IMP IMP: Inferred from mutant phenotype	24870230	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	15147888	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24608264	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	15147888	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15147888	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15147888	GOA
part of tRNA-splicing ligase complex	IDA IDA: Inferred from direct assay	21311021	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTRAF Protein Structure

RLL

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

RNA transcription, translation and transport factor protein

CLE7 homolog

RTRAF Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTRAF	Q9Y224	FAM98B	Homo sapiens	Q52LJ0	TAP	24608264
Intra	RTRAF	Q9Y224	FAM98B	Homo sapiens	Q52LJ0	Crosslink	30021884
Intra	RTRAF	Q9Y224	FAM98A	Homo sapiens	Q8NCA5	Y2H Array	31515488
Intra	RTRAF	Q9Y224	DDX1	Homo sapiens	Q92499	Crosslink	30021884
Intra	RTRAF	Q9Y224	FAM98A	Homo sapiens	Q8NCA5	TAP	24608264
Intra	RTRAF	Q9Y224	RTRAF	Homo sapiens	Q9Y224	Y2H	15147888
Intra	RTRAF	Q9Y224	FAM98A	Homo sapiens	Q8NCA5	Anti Tag CoIP	28040436
Intra	RTRAF	Q9Y224	RTRAF	Homo sapiens	Q9Y224	GMS	24608264
Intra	RTRAF	Q9Y224	DDX1	Homo sapiens	Q92499	TAP	24608264
Intra	RTRAF	Q9Y224	FAM98A	Homo sapiens	Q8NCA5	Y2H Array	25416956
Intra	RTRAF	Q9Y224	RTCB	Homo sapiens	Q9Y3I0	Pull Down	30833792
Intra	RTRAF	Q9Y224	RTRAF	Homo sapiens	Q9Y224	Pull Down	15147888
Intra	RTRAF	Q9Y224	RTRAF	Homo sapiens	Q9Y224	Comig Non-Denat Gel	24608264
Intra	RTRAF	Q9Y224	RTCB	Homo sapiens	Q9Y3I0	TAP	24608264
Intra	RTRAF	Q9Y224	RTRAF	Homo sapiens	Q9Y224	Comigration in SDS	24608264
Intra	RTRAF	Q9Y224	NIN	Homo sapiens	Q8N4C6	IF	15147888
Intra	RTRAF	Q9Y224	NIN	Homo sapiens	Q8N4C6	Y2H	15147888
Intra	RTRAF	Q9Y224	C2orf49	Homo sapiens	Q9BVC5	Crosslink	30021884
Cross	RTRAF	Q9Y224	PA	Influenza A virus	P31343	Pull Down	11507205
Cross	RTRAF	Q9Y224	PA	Influenza A virus	P31343	Y2H	11507205
Cross	RTRAF	Q9Y224	PA	Influenza A virus	Q67020	BiFC	21994455
Cross	RTRAF	Q9Y224	PA	Influenza A virus	Q67020	Y2H	21994455

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Central Nervous System Germinoma

Germinoma Of The Central Nervous System	Intracranial Germinoma
Germinoma Of Cns

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12341	RTRAF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RTRAF	VGNC	VGNC:77087
Rattus norvegicus	RTRAF	RGD	RGD:1304704
Mus musculus	RTRAF	MGD	MGI:1915295
Felis catus	RTRAF	VGNC	VGNC:103749
Bos taurus	RTRAF	VGNC	VGNC:49536

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