UBXN2A - UBX domain protein 2A Gene

Homo sapiens

Also known as UBXD4

Gene ID: 165324 | Gene type: protein coding

About UBXN2A

This gene has 4 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 3.2), esophagus (RPKM 2.9) and 25 other tissues.

Summary

Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including autophagosome assembly; nuclear membrane reassembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; regulation of gene expression; and regulation of protein metabolic process. Predicted to be located in cis-Golgi network and endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBXN2A Products(1)

mRNA	Protein	Name
NM_181713.4	NP_859064.2	UBX domain-containing protein 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	26265139	GOA
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	26634371	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	37037900	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24625977	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24625977	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN2A Protein Structure

SEP

UBX

0
100
200
259 a.a.

Protein Preferred Names

Protein Names

UBX domain-containing protein 2A

UBX domain containing 4

UBXN2A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBXN2A	P68543	UBXN6	Homo sapiens	Q9BZV1	Validated Y2H	32296183
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Y2H Prey Pooling	32296183
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	BRET	29997244
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Y2H Array	32296183
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Anti Tag CoIP	28514442
Intra	UBXN2A	P68543	VCP	Homo sapiens	P55072	Lumier	29997244
Intra	UBXN2A	P68543	DYDC2	Homo sapiens	Q96IM9	Validated Y2H	32296183
Intra	UBXN2A	P68543	DYDC2	Homo sapiens	Q96IM9	Y2H Array	32296183
Intra	UBXN2A	P68543	DYDC2	Homo sapiens	Q96IM9	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15396	UBXN2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UBXN2A	VGNC	VGNC:79657
Canis familiaris	UBXN2A	VGNC	VGNC:48098
Mus musculus	UBXN2A	MGD	MGI:2442310
Felis catus	UBXN2A	VGNC	VGNC:66792
Bos taurus	UBXN2A	VGNC	VGNC:36625
Rattus norvegicus	UBXN2A	RGD	RGD:1589027

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