UBXN6 - UBX domain protein 6 Gene

Homo sapiens

Also known as UBXD1; UBXDC2

Gene ID: 80700 | Gene type: protein coding

About UBXN6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,445,006-4,457,879 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 49.0), kidney (RPKM 36.6) and 25 other tissues.

Summary

Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Is extrinsic component of membrane. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

UBXN6 Products(2)

mRNA	Protein	Name
NM_001171091.2	NP_001164562.1	UBX domain-containing protein 6 isoform 2
NM_025241.3	NP_079517.1	UBX domain-containing protein 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18656546	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	19275885	GOA
involved in endosome to lysosome transport via multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	21822278	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	27753622	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27753622	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19275885	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	21822278	GOA
located in endosome	IDA IDA: Inferred from direct assay	26475856	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	21822278	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	21822278	GOA
located in membrane	IDA IDA: Inferred from direct assay	19275885	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	21822278	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN6 Protein Structure

PUB

UBX

0
100
200
300
400
441 a.a.

Protein Preferred Names

Protein Names

UBX domain-containing protein 6

CTB-50L17.16

UBXN6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Validated Y2H	25416956
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Y2H Array	25416956
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	Q1RN33	Y2H Prey Pooling	25416956
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	UBXN2A	Homo sapiens	P68543	Anti Tag CoIP	33961781
Intra	UBXN6	Q9BZV1	SVIP	Homo sapiens	Q8NHG7	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	SVIP	Homo sapiens	Q8NHG7	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	SUSD6	Homo sapiens	Q92537	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	SUSD6	Homo sapiens	Q92537	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Bait CoIP	18656546
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Tag CoIP	33961781
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	BRET	29997244
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Pull Down	18656546
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Lumier	29997244
Intra	UBXN6	Q9BZV1	VCP	Homo sapiens	P55072	Anti Tag CoIP	18775313
Intra	UBXN6	Q9BZV1	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Array	32296183
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Prey Pooling	32296183
Intra	UBXN6	Q9BZV1	MAGEA4	Homo sapiens	P43358	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1

Ibmpfd1	Msp1
Multisystem Proteinopathy 1

Multisystem Proteinopathy

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15398	UBXN6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UBXN6	VGNC	VGNC:36628
Macaca mulatta	UBXN6	VGNC	VGNC:78971
Canis familiaris	UBXN6	VGNC	VGNC:48101
Rattus norvegicus	UBXN6	RGD	RGD:1590866
Felis catus	UBXN6	VGNC	VGNC:80752
Mus musculus	UBXN6	MGD	MGI:1913780

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