RNF168 - ring finger protein 168 Gene

Homo sapiens

Also known as RIDL; hRNF168

Gene ID: 165918 | Gene type: protein coding

About RNF168

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,468,783-196,503,768 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in testis (RPKM 13.5), bone marrow (RPKM 9.5) and 24 other tissues.

Summary

This gene encodes an E3 ubiquitin Ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]

RNF168 Products(1)

mRNA	Protein	Name
NM_152617.4	NP_689830.2	E3 ubiquitin-protein ligase RNF168

RNF168 Protein Structure

zf-C3HC4_2

0
100
200
300
400
500
571 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF168

RING-type E3 ubiquitin transferase RNF168

RNF168 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF168	Q8IYW5	UBE2N	Homo sapiens	P61088	Anti Bait CoIP	19203578
Intra	RNF168	Q8IYW5	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	RNF168	Q8IYW5	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	RNF168	Q8IYW5	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	RNF168	Q8IYW5	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	32296183
Intra	RNF168	Q8IYW5	ALAS1	Homo sapiens	P13196	Y2H Array	32296183
Intra	RNF168	Q8IYW5	RNF11	Homo sapiens	Q9Y3C5	Y2H	15231748
Intra	RNF168	Q8IYW5	H1-0	Homo sapiens	P07305	Pull Down	26503038

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Riddle Syndrome

RIDL	Radiosensitivity-Immunodeficiency-Dysmorphic Features-Learning Difficulties Syndrome
Rnf168 Deficiency	Radiosensitivity, Immunodeficiency, Dysmorphic Facial Features, And Learning Difficulties
Radiosensitivity, Immunodeficiency, Dysmorphic Features, And Learning Difficulties

Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency	IMD46
Cid Due To Tfrc Deficiency	Combined Immunodeficiency Due To Tfrc Deficiency

Chromosome 3q29 Duplication Syndrome

Chromosome 3q29 Microduplication Syndrome	Trisomy 3q29
Microduplication 3q29 Syndrome	3q29 Microduplication
3q29 Microduplication Syndrome	3q29 Interstitial Microduplication

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4	AGM4
Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect	B Cell Linker Protein Deficiency
B-Cell Linker Protein Deficiency	Blnk Deficiency
Agammaglobulinemia Autosomal Recessive Due To Blnk Defect	Agammaglobulinemia, Type 4, Autosomal Recessive

Lig4 Syndrome

Dna Ligase Iv Deficiency	Ligase 4 Syndrome
LIG4S

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151799	P62-RNF168 agonist-1		98.62%	Unkown
HY-RS12062	RNF168 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF168	RGD	RGD:1585168
Bos taurus	RNF168	VGNC	VGNC:97307
Macaca mulatta	RNF168	VGNC	VGNC:76840
Felis catus	RNF168	VGNC	VGNC:101463
Mus musculus	RNF168	MGD	MGI:1917488
Canis familiaris	RNF168	VGNC	VGNC:45643

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