2. Gene
  3. LIX1 - limb and CNS expressed 1 Gene

LIX1 - limb and CNS expressed 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Lft; C5orf11

Gene ID: 167410 | Gene type: protein coding

About LIX1

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:97,091,867-97,142,611 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 2 paralogues. Biased expression in brain (RPKM 14.2), thyroid (RPKM 2.1) and 1 other tissue.

Summary

Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LIX1 Products(1)

mRNA Protein Name
NM_153234.5 NP_694966.3 protein limb expression 1 homolog
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIX1 Protein Structure

LIX1

LIX1: Limb expression 1 (10 - 259)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

protein limb expression 1 homolog

Lix1 homolog

LIX1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LIX1 Q8N485 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
LIX1 Q8N485 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
LIX1 Q8N485 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
LIX1 Q8N485 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
LIX1 Q8N485 TSACC Homo sapiens Q96A04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
3-Methylglutaconic Aciduria, Type Iv

3-Methylglutaconic Aciduria Type 4

Mga4

MGCA4

3-Methylglutaconic Aciduria Type Iv

Mga, Type Iv

Mga Type Iv

Not Otherwise Specified 3-Mga-Uria Type

3 Alpha Methylglutaconic Aciduria Type Iv

3 Methylglutaconic Aciduria Type Iv
Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax
3-Methylglutaconic Aciduria, Type I

3-Methylglutaconyl-Coa Hydratase Deficiency

3-Methylglutaconic Aciduria Type 1

Mga1

MGCA1

3mg-Coa Hydratase Deficiency

Mga Type I

Mga, Type I

3-Mg-Coa-Hydratase Deficiency

3 Methylglutaconyl Coa Hydratase Deficiency

3-Methylglutaconic Aciduria Type I

3 Alpha Methylglutaconic Aciduria Type I

3 Methylglutaconic Aciduria Type 1

3-Mgca Type I

3mg Coa Hydratase Deficiency

Auh Defect

Primary 3-Methylglutaconic Aciduria

3-Methylglutaconic Aciduria 1

3-Alpha-Methylglutaconic Aciduria Type 1

3-Alpha-Methylglutaconyl-Coa Hydratase Deficiency

3-@Methylglutaconic Aciduria, Type I

Megaloblastic Anemia Due To Inborn Errors Of Metabolism
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Aceruloplasminemia

Cerebellar Ataxia

Hypoceruloplasminemia

Hemosiderosis, Systemic, Due To Aceruloplasminemia

Familial Apoceruloplasmin Deficiency

Hereditary Ceruloplasmin Deficiency

Deficiency Of Ferroxidase

Hypoceruloplasminemia, Hereditary

Ceruloplasmin Deficiency

Systemic Hemosiderosis Due To Aceruloplasminemia

ACERULOP
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07698 LIX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07699 LIX1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LIX1 VGNC VGNC:102244
Canis familiaris LIX1 VGNC VGNC:42702
Mus musculus LIX1 MGD MGI:1913893
Bos taurus LIX1 VGNC VGNC:30912
Macaca mulatta LIX1 VGNC VGNC:74311
Rattus norvegicus LIX1 RGD RGD:1309454