Lrp8 - low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Gene

Mus musculus

Also known as Lr8b; ApoER2; 4932703M08Rik

Gene ID: 16975 | Gene type: protein coding

About Lrp8

Summary

Enables several functions, including amyloid-beta binding activity; Apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of CREB transcription factor activity; and regulation of dendrite development. Acts upstream of or within central nervous system development and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Lrp8 Products(6)

mRNA	Protein	Name
NM_001080926.1	NP_001074395.1	low-density lipoprotein receptor-related protein 8 isoform b precursor
NM_001369051.1	NP_001355980.1	low-density lipoprotein receptor-related protein 8 isoform c precursor
NM_001369052.1	NP_001355981.1	low-density lipoprotein receptor-related protein 8 isoform d
NM_001369053.1	NP_001355982.1	low-density lipoprotein receptor-related protein 8 isoform e
NM_001369054.1	NP_001355983.1	low-density lipoprotein receptor-related protein 8 isoform e
NM_053073.3	NP_444303.2	low-density lipoprotein receptor-related protein 8 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	16227578	MGI
enables apolipoprotein binding	IDA IDA: Inferred from direct assay	10571240	MGI
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	10571240	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10571240	MGI
enables reelin receptor activity	IDA IDA: Inferred from direct assay	10571241	MGI
enables reelin receptor activity	IMP IMP: Inferred from mutant phenotype	18778775	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ammon gyrus development	IMP IMP: Inferred from mutant phenotype	18778775	MGI
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	18778775	MGI
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	18778775	MGI
acts upstream of or within hippocampus development	IGI IGI: Inferred from genetic interaction	17330141	MGI
acts upstream of or within layer formation in cerebral cortex	IGI IGI: Inferred from genetic interaction	17330141	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	18778775	MGI
involved in positive regulation of dendrite development	IGI IGI: Inferred from genetic interaction	18778775	MGI
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21852430	MGI
acts upstream of or within positive regulation of protein kinase activity	IGI IGI: Inferred from genetic interaction	12526740	MGI
involved in reelin-mediated signaling pathway	IDA IDA: Inferred from direct assay	10571241	MGI
involved in reelin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18778775	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	29336888	MGI
involved in regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	29336888	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	16102539	MGI
involved in regulation of postsynaptic neurotransmitter receptor activity	IMP IMP: Inferred from mutant phenotype	16102539	MGI
involved in ventral spinal cord development	IEP IEP: Inferred from expression pattern	20711475	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	16102539	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	16102539	MGI
located in cell surface	IDA IDA: Inferred from direct assay	16227578	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15950758	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16102539	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	16102539	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	16102539	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	16102539	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	16102539	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	16102539	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 8

apolipoprotein E receptor 2

low density lipoprotein receptor relative, 8 ligand binding repeats, brain

Lrp8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lrp8	Q924X6	Dlg4	Mus musculus	Q62108	Anti Tag CoIP	16332682
Intra	Lrp8	Q924X6	Grin1	Mus musculus	P35438	Anti Bait CoIP	16332682
Intra	Lrp8	Q924X6	Reln	Mus musculus	Q60841	Anti Bait CoIP	10571241
Intra	Lrp8	Q924X6	Reln	Mus musculus	Q60841	Pull Down	10571241

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07802	LRP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp8	NCBI	NCBI:7804

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