2. Gene
  3. Lta4h - leukotriene A4 hydrolase Gene

Lta4h - leukotriene A4 hydrolase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 16993 | Gene type: protein coding

About Lta4h

Summary

The protein encoded by this gene is an Enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Lta4h Products(2)

mRNA Protein Name
NM_001313897.1 NP_001300826.1 leukotriene A-4 hydrolase isoform 2
NM_008517.2 NP_032543.2 leukotriene A-4 hydrolase isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukotriene A-4 hydrolase

LTA-4 hydrolase

LTA4 hydrodase

tripeptide aminopeptidase LTA4H

Recombinant Lta4h Proteins

Cat. No. Product Name Accession Purity
HY-P74776 Leukotriene A4 Hydrolase/LTA4H Protein, Mouse (sf9, His) P24527 (M1-D611) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137298 LYS006 Inhibitor 98.61% Unkown
HY-W027340 ARM1 Inhibitor 99.60% Unkown
HY-W004291 Methyl arachidate Inhibitor ≥98.0% Unkown
HY-10826 DG051 free acid Inhibitor / Unkown
HY-156960 JNJ-40929837 Inhibitor / Unkown
HY-156960A JNJ-40929837 succinate Inhibitor / Unkown
HY-160646 LTA4H-IN-3 Inhibitor / Unkown
HY-161349 LTA4H-IN-4 Inhibitor / Unkown
HY-162710 LTA4H-IN-5 Inhibitor / Unkown
HY-N8760 Batatasin IV Inhibitor / Unkown
HY-RS07871 LTA4H Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W004291R Methyl arachidate (Standard) Inhibitor / Unkown
HY-162015 LTA4H-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lta4h NCBI NCBI:4048