2. Gene
  3. LTA4H - leukotriene A4 hydrolase Gene

LTA4H - leukotriene A4 hydrolase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 4048 | Gene type: protein coding

About LTA4H

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:96,000,753-96,043,520 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues.

Summary

The protein encoded by this gene is an Enzyme that contains both hydrolase and Aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The Aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

LTA4H Products(7)

mRNA Protein Name
NM_000895.3 NP_000886.1 leukotriene A-4 hydrolase isoform 1
NM_001256643.1 NP_001243572.1 leukotriene A-4 hydrolase isoform 2
NM_001256644.1 NP_001243573.1 leukotriene A-4 hydrolase isoform 3
NM_001414263.1 NP_001401192.1 leukotriene A-4 hydrolase isoform 4
NM_001414264.1 NP_001401193.1 leukotriene A-4 hydrolase isoform 5
NM_001414265.1 NP_001401194.1 leukotriene A-4 hydrolase isoform 6
NM_001414266.1 NP_001401195.1 leukotriene A-4 hydrolase isoform 7
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
9774412 GOA
enables epoxide hydrolase activity IDA
IDA: Inferred from direct assay
15078870 GOA
enables epoxide hydrolase activity IMP
IMP: Inferred from mutant phenotype
11675384 GOA
enables leukotriene-A4 hydrolase activity IDA
IDA: Inferred from direct assay
9774412 GOA
enables metalloaminopeptidase activity IMP
IMP: Inferred from mutant phenotype
11675384 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
15078870 GOA
enables zinc ion binding IMP
IMP: Inferred from mutant phenotype
11675384 GOA
Biological Process GO Annotation Evidence Reference Source
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
9774412 GOA
involved in leukotriene biosynthetic process IMP
IMP: Inferred from mutant phenotype
11675384 GOA
involved in peptide catabolic process IDA
IDA: Inferred from direct assay
9774412 GOA
involved in protein metabolic process IMP
IMP: Inferred from mutant phenotype
11675384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTA4H Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (19 - 387)

Leuk-A4-hydro_C

Leuk-A4-hydro_C: Leukotriene A4 hydrolase, C-terminal (464 - 608)

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  • 611 a.a.
Protein Preferred Names Protein Names

leukotriene A-4 hydrolase

LTA-4 hydrolase

LTA4H Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LTA4H P09960 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
Intra
LTA4H P09960 TINF2 Homo sapiens Q9BSI4
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LTA4H Proteins

Cat. No. Product Name Accession Purity
HY-P70277 Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His) P09960-1 (M1-D611) ≥95%
HY-P73275 Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His) P09960-1/NP_000886.1 (M1-D611) ≥95%

Related Diseases

Diseases Alias
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Soft Palate Cancer

Malignant Tumor Of Soft Palate

Malignant Tumor Of The Soft Palate

Palate Cancer Soft Palate
Lymph Node Tuberculosis

King'S Evil

Scrofula

Tuberculous Adenitis

Tuberculous Lymphadenopathy

Tuberculosis, Lymph Node
Psoriasis
Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1
Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0494 Bufexamac Inhibitor ≥98.0% Unkown
Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137298 LYS006 Inhibitor 98.61% Unkown
HY-W027340 ARM1 Inhibitor 99.60% Unkown
HY-W004291 Methyl arachidate Inhibitor ≥98.0% Unkown
HY-10826 DG051 free acid Inhibitor / Unkown
HY-156960 JNJ-40929837 Inhibitor / Unkown
HY-156960A JNJ-40929837 succinate Inhibitor / Unkown
HY-160646 LTA4H-IN-3 Inhibitor / Unkown
HY-161349 LTA4H-IN-4 Inhibitor / Unkown
HY-162710 LTA4H-IN-5 Inhibitor / Unkown
HY-N8760 Batatasin IV Inhibitor / Unkown
HY-RS07871 LTA4H Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W004291R Methyl arachidate (Standard) Inhibitor / Unkown
HY-162015 LTA4H-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LTA4H VGNC VGNC:68100
Canis familiaris LTA4H VGNC VGNC:42853
Rattus norvegicus LTA4H RGD RGD:1311333
Macaca mulatta LTA4H VGNC VGNC:74453
Mus musculus LTA4H MGD MGI:96836
Bos taurus LTA4H VGNC VGNC:31067
Others LTA4H NCBI