Sphk1 - sphingosine kinase 1 Gene

Rattus norvegicus

Gene ID: 170897 | Gene type: protein coding

About Sphk1

Primary_assembly 10: 101,758,711-101,764,240 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 277 orthologues, 4 paralogues and is associated with 7 phenotypes. Biased expression in Thymus (RPKM 63.), Kidney (RPKM 34.3) and 7 other tissues.

Summary

Enables D-erythro-sphingosine kinase activity. Involved in several processes, including cyclooxygenase pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of macromolecule metabolic process. Located in several cellular components, including axon; cytosol; and synaptic vesicle. Biomarker of adenocarcinoma and high grade glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SphK1 (sphingosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sphk1 Products(6)

mRNA	Protein	Name
NM_001270809.1	NP_001257738.1	sphingosine kinase 1 isoform b
NM_001270807.1	NP_001257736.1	sphingosine kinase 1 isoform b
NM_001270808.1	NP_001257737.1	sphingosine kinase 1 isoform b
NM_133386.3	NP_596877.2	sphingosine kinase 1 isoform b
NM_001270811.1	NP_001257740.1	sphingosine kinase 1 isoform a
NM_001270810.1	NP_001257739.1	sphingosine kinase 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-erythro-sphingosine kinase activity	IDA IDA: Inferred from direct assay	15715670	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16888242	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	16135093	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17158340	RGD
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	16959847	RGD
involved in cyclooxygenase pathway	IDA IDA: Inferred from direct assay	18723875	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	18723875	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17158340	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	28284343	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17200676	RGD
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	28284343	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15289497	RGD
involved in positive regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	17325039	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16313513	RGD
involved in regulation of neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	28284343	RGD
involved in regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28284343	RGD
involved in response to ATP	IEP IEP: Inferred from expression pattern	17200676	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	17164439	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	15855330	RGD
involved in response to magnesium ion	IEP IEP: Inferred from expression pattern	18028875	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15715670	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	17164439	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17325039	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	17325039	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sphk1 Protein Structure

PLN02958

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

sphingosine kinase 1

SK 1	SPK 1
acetyltransferase SPHK1

Related Agents

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15425	PF-543	Inhibitor	99.85%	Unkown
HY-15425A	PF-543 Citrate	Inhibitor	99.47%	Unkown
HY-124042	K6PC-5	Activator	99.27%	Unkown
HY-12892	SKI-178	Inhibitor	98.91%	Unkown
HY-101572	MHP	Activator	98.23%	Unkown
HY-19794	MP-A08	Inhibitor	≥98.0%	Unkown
HY-147282	Amgen-23	Inhibitor	99.00%	Unkown
HY-101805	SK1-IN-1	Inhibitor	98.72%	Unkown
HY-119016A	SK1-I hydrochloride	Inhibitor	99.49%	Unkown
HY-148707	SphK1&2-IN-1	Inhibitor	99.33%	Unkown
HY-150615	SphK1-IN-2	Inhibitor	/	Unkown
HY-148262	SphK1-IN-3	Inhibitor	/	Unkown
HY-143296	SphK1-IN-1	Inhibitor	/	Unkown
HY-12900	RB-005	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sphk1	NCBI	NCBI:8877

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