SPHK1 - sphingosine kinase 1 Gene

Homo sapiens

Also known as SPHK

Gene ID: 8877 | Gene type: protein coding

About SPHK1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,383,204-76,387,855 (from NCBI)

This gene has 10 transcripts (splice variants), 277 orthologues and 4 paralogues. Ubiquitous expression in gall bladder (RPKM 4.9), esophagus (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

SPHK1 Products(5)

mRNA	Protein	Name
NM_001142602.2	NP_001136074.1	sphingosine kinase 1 isoform 3
NM_021972.4	NP_068807.2	sphingosine kinase 1 isoform 1
NM_182965.3	NP_892010.2	sphingosine kinase 1 isoform 2
NM_001142601.2	NP_001136073.1	sphingosine kinase 1 isoform 3
NM_001355139.2	NP_001342068.1	sphingosine kinase 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12393916	GOA
enables D-erythro-sphingosine kinase activity	IDA IDA: Inferred from direct assay	10863092	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	12393916	GOA
enables calmodulin binding	IDA IDA: Inferred from direct assay	10947957	GOA
enables lipid binding	IDA IDA: Inferred from direct assay	24929359	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10947957	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12080051	GOA
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	21075214	GOA
enables sphingosine kinase activity	IDA IDA: Inferred from direct assay	12393916	GOA
enables sphingosine-1-phosphate receptor activity	IMP IMP: Inferred from mutant phenotype	23106337	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	10947957	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	25417698	GOA
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15623571	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16118219	GOA
involved in negative regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	16118219	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20577214	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	12441135	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	12441135	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	12441135	GOA
acts upstream of or within positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	15623571	GOA
involved in positive regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	12441135	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	20577214	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	23935096	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	20577214	GOA
involved in positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	12847068	GOA
involved in regulation of endocytosis	IDA IDA: Inferred from direct assay	24929359	GOA
involved in regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	20577214	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	23935096	GOA
involved in sphingosine biosynthetic process	IGI IGI: Inferred from genetic interaction	23106337	GOA
involved in sphingosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	23106337	GOA
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	20577214	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	24929359	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15623571	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	24929359	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19854831	GOA
is active in presynapse	IDA IDA: Inferred from direct assay	24929359	GOA
is active in presynapse	IMP IMP: Inferred from mutant phenotype	24929359	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPHK1 Protein Structure

DAGK_cat

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

sphingosine kinase 1

SK 1	SPK 1
acetyltransferase SPHK1

SPHK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPHK1	Q9NYA1	SPHKAP	Homo sapiens	Q2M3C7	Pull Down	12080051
Intra	SPHK1	Q9NYA1	SPHKAP	Homo sapiens	Q2M3C7	Y2H	12080051
Intra	SPHK1	Q9NYA1	EEF1A1	Homo sapiens	P68104	Pull Down	20838377
Intra	SPHK1	Q9NYA1	FHL2	Homo sapiens	Q14192	IF	16888242
Intra	SPHK1	Q9NYA1	CTSB	Homo sapiens	P07858	Protease Assay	17064696

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPHK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73631	SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST)	Q9NYA1 (M1-L384)	≥95%

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Waardenburg Syndrome, Type 2b

Waardenburg Syndrome Type 2b	WS2B
Waardenburg Syndrome, Type Iib	Waardenburg Syndrome Type Iib

Renal Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15425	PF-543	Inhibitor	99.85%	Unkown
HY-15425A	PF-543 Citrate	Inhibitor	99.47%	Unkown
HY-124042	K6PC-5	Activator	99.27%	Unkown
HY-101572	MHP	Activator	98.23%	Unkown
HY-12892	SKI-178	Inhibitor	98.91%	Unkown
HY-19794	MP-A08	Inhibitor	≥98.0%	Unkown
HY-147282	Amgen-23	Inhibitor	99.00%	Unkown
HY-101805	SK1-IN-1	Inhibitor	98.72%	Unkown
HY-119016A	SK1-I hydrochloride	Inhibitor	99.49%	Unkown
HY-148707	SphK1&2-IN-1	Inhibitor	99.33%	Unkown
HY-150615	SphK1-IN-2	Inhibitor	/	Unkown
HY-148262	SphK1-IN-3	Inhibitor	/	Unkown
HY-143296	SphK1-IN-1	Inhibitor	/	Unkown
HY-12900	RB-005	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPHK1	RGD	RGD:620048
Mus musculus	SPHK1	MGD	MGI:1316649
Macaca mulatta	SPHK1	VGNC	VGNC:77858
Canis familiaris	SPHK1	VGNC	VGNC:49655
Felis catus	SPHK1	VGNC	VGNC:65635
Bos taurus	SPHK1	VGNC	VGNC:35210
Others	SPHK1	NCBI

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