2. Gene
  3. Havcr2 - hepatitis A virus cellular receptor 2 Gene

Havcr2 - hepatitis A virus cellular receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tim3; TIM-3; Timd3

Gene ID: 171285 | Gene type: protein coding

About Havcr2

Summary

Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and Toll-like Receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Havcr2 Products(1)

mRNA Protein Name
NM_134250.2 NP_599011.2 hepatitis A virus cellular receptor 2 homolog precursor
Protein Preferred Names Protein Names

hepatitis A virus cellular receptor 2 homolog

HAVcr-2

T-cell immunoglobulin and mucin domain containing 3

T-cell immunoglobulin and mucin domain-containing protein 3

T-cell immunoglobulin mucin receptor 3

T-cell membrane protein 3

TIMD-3

Havcr2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra Havcr2 Q8VIM0 Lgals9 Mus musculus O08573-2
Pull Down
16286920
Intra Havcr2 Q8VIM0 Hmgb1 Mus musculus P63158
Confocal
22842346
Intra Havcr2 Q8VIM0 Hmgb1 Mus musculus P63158
ELISA
22842346
Intra Havcr2 Q8VIM0 Hmgb1 Mus musculus P63158
Anti Tag CoIP
22842346
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Havcr2 Proteins

Cat. No. Product Name Accession Purity
HY-P70826 TIM-3/HAVCR2 Protein, Mouse (HEK293, Fc) Q8VIM0-1 (R20-R191) ≥95%
HY-P71995 TIM-3/HAVCR2 Protein, Mouse (HEK 293, hFc) Q8VIM0-1 (R20-R191) ≥95%
HY-P72448 TIM-3/HAVCR2 Protein, Mouse (HEK293, His) Q8VIM0-1 (R20-R191) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06022 HAVCR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990701 Lomvastomig / Unkown
HY-P990716 Sabestomig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Havcr2 NCBI NCBI:84868
Macaca fascicularis Havcr2 NCBI NCBI:102141722