Havcr2 - hepatitis A virus cellular receptor 2 Gene

Mus musculus

Also known as Tim3; TIM-3; Timd3

Gene ID: 171285 | Gene type: protein coding

About Havcr2

Summary

Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and Toll-like Receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Havcr2 Products(1)

mRNA	Protein	Name
NM_134250.2	NP_599011.2	hepatitis A virus cellular receptor 2 homolog precursor

Protein Preferred Names

Protein Names

hepatitis A virus cellular receptor 2 homolog

HAVcr-2	T-cell immunoglobulin and mucin domain containing 3
T-cell immunoglobulin and mucin domain-containing protein 3	T-cell immunoglobulin mucin receptor 3
T-cell membrane protein 3	TIMD-3

Havcr2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Havcr2	Q8VIM0	Lgals9	Mus musculus	O08573-2	Pull Down	16286920
Intra	Havcr2	Q8VIM0	Hmgb1	Mus musculus	P63158	Confocal	22842346
Intra	Havcr2	Q8VIM0	Hmgb1	Mus musculus	P63158	ELISA	22842346
Intra	Havcr2	Q8VIM0	Hmgb1	Mus musculus	P63158	Anti Tag CoIP	22842346

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Havcr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70826	TIM-3/HAVCR2 Protein, Mouse (HEK293, Fc)	Q8VIM0-1 (R20-R191)	≥95%
HY-P71995	TIM-3/HAVCR2 Protein, Mouse (HEK 293, hFc)	Q8VIM0-1 (R20-R191)	≥95%
HY-P72448	TIM-3/HAVCR2 Protein, Mouse (HEK293, His)	Q8VIM0-1 (R20-R191)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990085	Verzistobart	Inhibitor	/	Phase 2
HY-P990701	Lomvastomig		/	Phase 2
HY-P990716	Sabestomig		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06022	HAVCR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Havcr2	NCBI	NCBI:84868
Macaca fascicularis	Havcr2	NCBI	NCBI:102141722

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