2. Gene
  3. Epcam - epithelial cell adhesion molecule Gene

Epcam - epithelial cell adhesion molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Egp314; Tacstd1

Gene ID: 171577 | Gene type: protein coding

About Epcam

Summary

Enables cadherin binding activity involved in cell-cell adhesion. Involved in cell-cell adhesion via plasma-membrane adhesion molecules; negative regulation of apoptotic process; and positive regulation of cell motility. Located in bicellular tight junction; cell surface; and lateral plasma membrane. Is integral component of membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal Cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

Epcam Products(1)

mRNA Protein Name
NM_138541.2 NP_612550.1 epithelial cell adhesion molecule precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cadherin binding involved in cell-cell adhesion IPI
IPI: Inferred from physical interaction
19276185 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: Inferred from direct assay
19276185 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
19276185 RGD
involved in positive regulation of cell motility IDA
IDA: Inferred from direct assay
19276185 RGD
Cellular Component GO Annotation Evidence Reference Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16054130 RGD
located in cell surface IDA
IDA: Inferred from direct assay
19276185 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
16054130 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epithelial cell adhesion molecule

ep-CAM

epithelial glycoprotein 314

tumor-associated calcium signal transducer 1

Recombinant Epcam Proteins

Cat. No. Product Name Accession Purity
HY-P74172 EpCAM/TROP1 Protein, Rat (HEK293, His) O55159 (Q24-T266) ≥95%
HY-P74173 EpCAM/TROP1 Protein, Rat (HEK293, Fc) O55159 (Q24-T266) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111183 Neocarzinostatin ≥99.0% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9954 Catumaxomab 98.56% Unkown
Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99328 Tucotuzumab ≥95.0% Phase 2
HY-P99592 Solitomab Inhibitor 98.15% Phase 1
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15897 LDN-212854 Inhibitor 99.70% Unkown
HY-RS04420 EPCAM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epcam NCBI NCBI:4072
Macaca fascicularis Epcam NCBI NCBI:102123042
Mus musculus Epcam NCBI NCBI:17075
Macaca mulatta Epcam NCBI NCBI:677680