2. Gene
  3. Mmp12 - matrix metallopeptidase 12 Gene

Mmp12 - matrix metallopeptidase 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MME; Mmel

Gene ID: 17381 | Gene type: protein coding

About Mmp12

Chromosome 9: 7,344,381-7,369,499 forward strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 559 orthologues, 23 paralogues and is associated with 5 phenotypes.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon Bacterial infection. This gene is located in a cluster of Other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

Mmp12 Products(3)

mRNA Protein Name
NM_008605.3 NP_032631.3 macrophage metalloelastase isoform 1 preproprotein
NM_001320076.1 NP_001307005.1 macrophage metalloelastase isoform 2
NM_001320077.1 NP_001307006.1 macrophage metalloelastase isoform 3
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within bronchiole development IDA
IDA: Inferred from direct assay
12634787 MGI
acts upstream of or within bronchiole development IMP
IMP: Inferred from mutant phenotype
12634787 MGI
involved in cellular response to virus IMP
IMP: Inferred from mutant phenotype
24784232 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
12634787 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24784232 MGI
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24784232 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24784232 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
24784232 MGI
involved in positive regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24784232 MGI
involved in protein import into nucleus IMP
IMP: Inferred from mutant phenotype
24784232 MGI
involved in regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
24784232 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
24784232 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24784232 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage metalloelastase

macrophage elastase

matrix metalloproteinase 12

Recombinant Mmp12 Proteins

Cat. No. Product Name Accession Purity
HY-P70342 MMP-12 Protein, Mouse (HEK293, His) P34960 (A29-C473) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156963 Aderamastat Inhibitor 98.16% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-120852 JG26 Inhibitor 98.01% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-135517 RXP470.1 Inhibitor / Unkown
HY-120944 BAY-7598 Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-130391 MMP12-IN-3 Inhibitor / Unkown
HY-161707 MMP2-IN-4 Inhibitor / Unkown
HY-P4521 Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt / Unkown
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor / Unkown
HY-RS08522 MMP12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08523 Mmp12 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08524 Mmp12 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-119185 AZD-6605 / Unkown
HY-14155 MMP145 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp12 NCBI NCBI:4321