2. Metabolic Enzyme/Protease
  3. MMP
  4. PF-00356231 hydrochloride

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively.

For research use only. We do not sell to patients.

PF-00356231 hydrochloride Chemical Structure

PF-00356231 hydrochloride Chemical Structure

CAS No. : 820223-77-6

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Based on 1 publication(s) in Google Scholar

Other Forms of PF-00356231 hydrochloride:

PF-00356231 hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PF-00356231 hydrochloride

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].

IC50 & Target[1]

MMP-12

1.4 μM (IC50)

MMP13

0.65 nM (IC50)

MMP-3

0.39 μM (IC50)

MMP-8

1.7 μM (IC50)

MMP-9

0.98 μM (IC50)

In Vitro

PF-00356231 hydrochloride against MMP-12/13 can be affected significantly by the presence of acetohydroxamate (AH). PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-00356231 hydrochloride Related Antibodies
Molecular Weight

464.96

Formula

C25H21ClN2O3S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC(C[C@H](C1=CC=CC=C1)NC(C2=CC(C3=CC=C(C4=CC=NC=C4)C=C3)=CS2)=O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (44.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1507 mL 10.7536 mL 21.5072 mL
5 mM 0.4301 mL 2.1507 mL 4.3014 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.52%

SDS (251 KB)

COA (250 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1507 mL 10.7536 mL 21.5072 mL 53.7681 mL
5 mM 0.4301 mL 2.1507 mL 4.3014 mL 10.7536 mL
10 mM 0.2151 mL 1.0754 mL 2.1507 mL 5.3768 mL
15 mM 0.1434 mL 0.7169 mL 1.4338 mL 3.5845 mL
20 mM 0.1075 mL 0.5377 mL 1.0754 mL 2.6884 mL
25 mM 0.0860 mL 0.4301 mL 0.8603 mL 2.1507 mL
30 mM 0.0717 mL 0.3585 mL 0.7169 mL 1.7923 mL
40 mM 0.0538 mL 0.2688 mL 0.5377 mL 1.3442 mL
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PF-00356231 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-00356231820223-77-6PF00356231PF 00356231MMPMatrix metalloproteinasesspecificnon-peptidicnon-zincchelatingligandcomplexS1pocketInhibitorinhibitorinhibit

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