2. Gene
  3. Mmp8 - matrix metallopeptidase 8 Gene

Mmp8 - matrix metallopeptidase 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 17394 | Gene type: protein coding

About Mmp8

Chromosome 9: 7,558,457-7,568,486 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 111 orthologues, 23 paralogues and is associated with 10 phenotypes. Biased expression in liver E18 (RPKM 19.) and liver E14.5 (RPKM .8).

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that degrades types I, II and III collagens. Mice lacking the encoded protein exhibit abnormalities in the inflammatory responses to various agents. This gene is located in a cluster of Other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp8 Products(1)

mRNA Protein Name
NM_008611.4 NP_032637.3 neutrophil collagenase preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
25049354 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
25049354 MGI
acts upstream of positive regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
25049354 MGI
involved in positive regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
25049354 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
25049354 MGI
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
25049354 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp8 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (30 - 85)

Peptidase_M10

Peptidase_M10: pfam00413 (106 - 261)

HX

HX: cd00094 (275 - 463)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
Protein Preferred Names Protein Names

neutrophil collagenase

collagenase-2

matrix metalloproteinase-8

Recombinant Mmp8 Proteins

Cat. No. Product Name Accession Purity
HY-P73808 MMP-8 Protein, Mouse (HEK293) O70138 (F21-S465) ≥95%
HY-P73809 MMP-8 Protein, Mouse (CHO, His) O70138 (M1-S465) ≥95%
HY-P78328 MMP-8 Protein, Mouse (HEK293, His) O70138 (F21-S465) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19485 XL-784 Inhibitor 98.13% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148905 p-Aminophenylmercuric acetate Activator 99.07% Unkown
HY-113952 Actinonin 98.61% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.80% Unkown
HY-P4931 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 99.87% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.73% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-128133 MMP-8 inhibitor-1 Inhibitor ≥98.0% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-147746 MMP2-IN-3 Inhibitor 99.64% Unkown
HY-147745 MMP2-IN-2 Inhibitor 98.80% Unkown
HY-110116 SD-2590 hydrochloride Inhibitor 99.1% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-RS08555 Mmp8 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114396 BR351 Inhibitor / Unkown
HY-137793 Pro-Leu-Gly-NHOH hydrochloride Inhibitor / Unkown
HY-162038 RXP03 Inhibitor / Unkown
HY-168605 DH-18 / Unkown
HY-P2682 MMP-8/MMP-26 Fluorogenic substrate / Unkown
HY-RS08554 MMP8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08556 Mmp8 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-35513 3-Aminobenzene-1,2-diol Inhibitor / Unkown
HY-43586 BR351 precursor Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp8 NCBI NCBI:4317
Macaca fascicularis Mmp8 NCBI NCBI:102141209