SD-2590 hydrochloride

Cat. No.: HY-110116 Purity: 99.1%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SD-2590 hydrochloride is a potent MMP inhibitor with IC₅₀ values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats.

For research use only. We do not sell to patients.

SD-2590 hydrochloride Chemical Structure

CAS No. : 226395-93-3

Size	Price	Stock	Quantity
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All MMP Isoform Specific Products:

View All Isoforms

MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

554.96

Formula

C₂₂H₂₆ClF₃N₂O₇S

CAS No.

226395-93-3

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1(CCN(CCOC)CC1)C(NO)=O)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 55.5 mg/mL (100.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8019 mL	9.0097 mL	18.0193 mL
5 mM	0.3604 mL	1.8019 mL	3.6039 mL
10 mM	0.1802 mL	0.9010 mL	1.8019 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.1%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (247 KB) Elemental Analysis Report (105 KB)

Handling Instructions (2659 KB)

References

[1]. Becker DP, et, al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J Med Chem. 2010 Sep 23;53(18):6653-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8019 mL	9.0097 mL	18.0193 mL	45.0483 mL
	5 mM	0.3604 mL	1.8019 mL	3.6039 mL	9.0097 mL
	10 mM	0.1802 mL	0.9010 mL	1.8019 mL	4.5048 mL
	15 mM	0.1201 mL	0.6006 mL	1.2013 mL	3.0032 mL
	20 mM	0.0901 mL	0.4505 mL	0.9010 mL	2.2524 mL
	25 mM	0.0721 mL	0.3604 mL	0.7208 mL	1.8019 mL
	30 mM	0.0601 mL	0.3003 mL	0.6006 mL	1.5016 mL
	40 mM	0.0450 mL	0.2252 mL	0.4505 mL	1.1262 mL
	50 mM	0.0360 mL	0.1802 mL	0.3604 mL	0.9010 mL
	60 mM	0.0300 mL	0.1502 mL	0.3003 mL	0.7508 mL
	80 mM	0.0225 mL	0.1126 mL	0.2252 mL	0.5631 mL
	100 mM	0.0180 mL	0.0901 mL	0.1802 mL	0.4505 mL