2. Metabolic Enzyme/Protease
  3. MMP
  4. SD-2590 hydrochloride

SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats.

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SD-2590 hydrochloride Chemical Structure

SD-2590 hydrochloride Chemical Structure

CAS No. : 226395-93-3

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Based on 1 publication(s) in Google Scholar

SD-2590 hydrochloride Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

SD-2590 hydrochloride is a potent MMP inhibitor with IC50 values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats[1].

Molecular Weight

554.96

Formula

C22H26ClF3N2O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1(CCN(CCOC)CC1)C(NO)=O)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 55.5 mg/mL (100.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8019 mL 9.0097 mL 18.0193 mL
5 mM 0.3604 mL 1.8019 mL 3.6039 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8019 mL 9.0097 mL 18.0193 mL 45.0483 mL
5 mM 0.3604 mL 1.8019 mL 3.6039 mL 9.0097 mL
10 mM 0.1802 mL 0.9010 mL 1.8019 mL 4.5048 mL
15 mM 0.1201 mL 0.6006 mL 1.2013 mL 3.0032 mL
20 mM 0.0901 mL 0.4505 mL 0.9010 mL 2.2524 mL
25 mM 0.0721 mL 0.3604 mL 0.7208 mL 1.8019 mL
30 mM 0.0601 mL 0.3003 mL 0.6006 mL 1.5016 mL
40 mM 0.0450 mL 0.2252 mL 0.4505 mL 1.1262 mL
50 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9010 mL
60 mM 0.0300 mL 0.1502 mL 0.3003 mL 0.7508 mL
80 mM 0.0225 mL 0.1126 mL 0.2252 mL 0.5631 mL
100 mM 0.0180 mL 0.0901 mL 0.1802 mL 0.4505 mL
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SD-2590 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-2590226395-93-3SD2590SD 2590MMPMatrix metalloproteinasesInhibitorinhibitorinhibit

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