DPYS - dihydropyrimidinase Gene

Homo sapiens

Also known as DHP; DHPase

Gene ID: 1807 | Gene type: protein coding

About DPYS

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,379,431-104,467,055 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 34.3) and kidney (RPKM 29.7).

Summary

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

DPYS Products(1)

mRNA	Protein	Name
NM_001385.3	NP_001376.1	dihydropyrimidinase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables dihydropyrimidinase activity	IDA IDA: Inferred from direct assay	9718352	GOA
enables dihydropyrimidinase activity	IMP IMP: Inferred from mutant phenotype	18075467	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in pyrimidine nucleobase catabolic process	IDA IDA: Inferred from direct assay	9718352	GOA
involved in uracil catabolic process	IDA IDA: Inferred from direct assay	10410956	GOA
involved in uracil catabolic process	IMP IMP: Inferred from mutant phenotype	18075467	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPYS Protein Structure

Amidohydro_1

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

dihydropyrimidinase

dihydropyrimidine amidohydrolase

Recombinant DPYS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75713	DPYS Protein, Human (sf9)	Q14117 (N-G&P, M1-P519)	≥95%
HY-P75714	DPYS Protein, Human (sf9, His-GST)	Q14117 (M1-P519)	≥95%

Related Diseases

Diseases

Alias

Dihydropyrimidinase Deficiency

Dihydropyrimidinuria	Dpys Deficiency
Dph Deficiency	DPYSD
Dihydrouracil Amidohydrolase Deficiency	Dihydropyrimidinuria Due To Dpys Deficiency

Dihydropyrimidine Dehydrogenase Deficiency

Dpd Deficiency	Familial Pyrimidinemia
Hereditary Thymine-Uraciluria	Dihydropyrimidinuria
Dpyd Deficiency	Thymine-Uraciluria, Hereditary
Pyrimidinemia, Familial	5-Fluorouracil Toxicity
Dihydrouracil Dehydrogenase Deficiency	Familial Pyrimidinaemia
Thymine-Uracilurea	Familial Pyrimidemia
Pyrimidinemia Familial	DPYDD

Pyrimidine Metabolic Disorder

Disorder Of Pyrimidine Metabolism

Pyrimidine Metabolism Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03976	DPY19L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03977	DPY19L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03978	DPY30 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03980	DPYS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DPYS	VGNC	VGNC:40082
Mus musculus	DPYS	MGD	MGI:1928679
Bos taurus	DPYS	VGNC	VGNC:28194
Macaca mulatta	DPYS	VGNC	VGNC:71983
Felis catus	DPYS	VGNC	VGNC:61614
Rattus norvegicus	DPYS	RGD	RGD:68376
Others	DPYS	NCBI

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