2. Gene
  3. DPYS - dihydropyrimidinase Gene

DPYS - dihydropyrimidinase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DHP; DHPase

Gene ID: 1807 | Gene type: protein coding

About DPYS

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,379,431-104,467,055 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 34.3) and kidney (RPKM 29.7).

Summary

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

DPYS Products(1)

mRNA Protein Name
NM_001385.3 NP_001376.1 dihydropyrimidinase

DPYS Protein Structure

Amidohydro_1

Amidohydro_1: Amidohydrolase family (59 - 407)

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  • 519 a.a.
Protein Preferred Names Protein Names

dihydropyrimidinase

dihydropyrimidine amidohydrolase

Recombinant DPYS Proteins

Cat. No. Product Name Accession Purity
HY-P75713 DPYS Protein, Human (sf9) Q14117 (N-G&P, M1-P519) ≥95%
HY-P75714 DPYS Protein, Human (sf9, His-GST) Q14117 (M1-P519) ≥95%

Related Diseases

Diseases Alias
Dihydropyrimidinase Deficiency

Dihydropyrimidinuria

Dpys Deficiency

Dph Deficiency

DPYSD

Dihydrouracil Amidohydrolase Deficiency

Dihydropyrimidinuria Due To Dpys Deficiency
Dihydropyrimidine Dehydrogenase Deficiency

Dpd Deficiency

Familial Pyrimidinemia

Hereditary Thymine-Uraciluria

Dihydropyrimidinuria

Dpyd Deficiency

Thymine-Uraciluria, Hereditary

Pyrimidinemia, Familial

5-Fluorouracil Toxicity

Dihydrouracil Dehydrogenase Deficiency

Familial Pyrimidinaemia

Thymine-Uracilurea

Familial Pyrimidemia

Pyrimidinemia Familial

DPYDD
Pyrimidine Metabolic Disorder

Disorder Of Pyrimidine Metabolism

Pyrimidine Metabolism Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03976 DPY19L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03977 DPY19L3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03978 DPY30 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03980 DPYS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DPYS VGNC VGNC:40082
Mus musculus DPYS MGD MGI:1928679
Bos taurus DPYS VGNC VGNC:28194
Macaca mulatta DPYS VGNC VGNC:71983
Felis catus DPYS VGNC VGNC:61614
Rattus norvegicus DPYS RGD RGD:68376
Others DPYS NCBI