SLC26A3 - solute carrier family 26 member 3 Gene

Homo sapiens

Also known as CLD; DRA

Gene ID: 1811 | Gene type: protein coding

About SLC26A3

Cytogenetic location: 7q22.3-q31.1 Genomic coordinates (GRCh38): 7:107,765,469-107,803,223 (from NCBI)

This gene has 5 transcripts (splice variants), 252 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in colon (RPKM 709.1), duodenum (RPKM 299.0) and 1 other tissue.

Summary

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]

SLC26A3 Products(1)

mRNA	Protein	Name
NM_000111.3	NP_000102.1	chloride anion exchanger

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	16606687	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12369822	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19321737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A3 Protein Structure

Sulfate_transp

STAS

0
200
400
600
764 a.a.

Protein Preferred Names

Protein Names

chloride anion exchanger

down-regulated in adenoma protein

Related Diseases

Diseases

Alias

Diarrhea 1, Secretory Chloride, Congenital

DIAR1	Chloride Diarrhea, Congenital, Finnish Type
Congenital Secretory Chloride Diarrhea 1	Congenital Chloride Diarrhea Finnish Type
Congenital Chloride Diarrhea	Chloridorrhea, Congenital
Congenital Chloride Diarrhoea Finnish Type	Congenital Chloridorrhea
Congenital Secretory Chloride Diarrhoea 1	Chloridorrhea Congenital
Cld	Diarrhea 1 Secretory Chloride Congenital
Diarrhea, Type 1, Chloride, Secretory, Congenital

Congenital Chloride Diarrhea

Familial Chloride Diarrhea	Chloride Diarrhea, Congenital, Finnish Type
Diarrhea 1	Cld
Chloridorrhea, Congenital	Congenital Chloridorrhea
Diar1	Darrow-Gamble Disease
Diarrhea 1, Secretory Chloride, Congenital

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Polyhydramnios

Hydrops Fetalis, Nonimmune

Hydrops Fetalis	Non-Immune Hydrops Fetalis
NIHF	Familial Non-Immune Hydrops Fetalis
Hydrops Fetalis Nonimmune	Idiopathic Hydrops Fetalis
Hb Bart'S Hydrops Fetalis	Alpha-Thalassemia Hydrops Fetalis
Alpha-Thalassemia Major	Hemoglobin Bart'S Hydrops Fetalis
Homozygous Alpha0-Thalassemia	Fetal Anasarca
Fetal Hydrops	Generalized Fetal Edema
Hf	Non-Immune Hf
Non-Immune Fetal Edema	Non-Immune Fetal Hydrops
Hydrops Fetalis, Non-Immune	Hemoglobin Bart'S Hydrops Syndrome

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Spermatocele

Colon Adenoma

Adenomatous Polyp Of Colon

Diastrophic Dysplasia

Diastrophic Dwarfism	DTD
Dd	Diastrophic Dysplasia, Broad Bone-Platyspondylic Variant
Dysplasia, Diastrophic	Diastrophic Dysplasia Variant

Pendred Syndrome

Goiter-Deafness Syndrome	Deafness With Goiter
PDS	Thyroid Dyshormonogenesis 2b
Tdh2b	Autosomal Recessive Sensorineural Hearing Impairment And Goiter
Pendred'S Syndrome	Thyroid Hormonogenesis, Genetic Defect In, 2b
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b	Congenital Hypothyroidism Due To Dyshormonogenesis 2b
Genetic Defect In Thyroid Hormonogenesis 2b	Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter
Goiter-Hearing Loss Syndrome	Goitre-Deafness Syndrome
Goitre Deafness

Orbital Tenonitis

Tenonitis

Inflammatory Diarrhea

Dialysis-Related Amyloidosis

Abeta2m Amyloidosis	Amyloidosis Beta2m
Beta2-Microglobulinic Amyloidosis	Variant Abeta2m Amyloidosis
Autosomal Dominant Beta2-Microglobulinic Amyloidosis	Aβ2m Amyloidosis
Dialysis-Related Beta2-Microglobulin Amyloidosis	Amyloidosis Dialysis-Related
Beta-2-Microglobulin Amyloidosis	Dra
Hemodialysis-Associated Amyloidosis

Secretory Diarrhea

Osmotic Diarrhea

Lactase Deficiency, Congenital

Congenital Lactase Deficiency	Disaccharide Intolerance Ii
Congenital Alactasia	Congenital Alactasia Syndrome
Congenital Lactose Intolerance	Congenital Lactose Malabsorption
Hereditary Alactasia	Alactasia, Congenital
Cld	COLACD
Disaccharide Intolerance Type 2	Cld - [Congenital Lactase Deficiency]
Disaccharide Intolerance 2	Lactose Intolerance Of Newborn
Hereditary Lactase Deficiency

Diarrhea 8, Secretory Sodium, Congenital

Congenital Secretory Sodium Diarrhea 8	DIAR8
Diarrhea, Congenital Sodium	Csd
Congenital Secretory Diarrhea, Sodium Type

Bartter Disease

Bartter Syndrome	Bartter'S Syndrome
Aldosteronism With Hyperplasia Of The Adrenal Cortex	Hypokalemic Alkalosis With Hypercalciuria
Potassium Wasting	Juxtaglomerular Hyperplasia With Secondary Aldosteronism
Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria	Salt-Losing Tubular Disorder, Henle'S Loop Type
Salt-Wasting Tubulopathy, Henle'S Loop Type	Bartters Syndrome

Diarrhea 5, With Tufting Enteropathy, Congenital

Congenital Diarrhea 5 With Tufting Enteropathy	Congenital Tufting Enteropathy
DIAR5	Cte
Intestinal Epithelial Cell Dysplasia	Tufting Enteropathy
Ied	Intestinal Epithelial Dysplasia
Enteropathy, Congenital Tufting	Congenital Diarrhoea 5 With Tufting Enteropathy
Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities	Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities
Congenital Enteropathy	Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities
Non-Syndromic Congenital Tufting Enteropathy	Diarrhea, Type 5, With Tufting Enteropathy, Congenital
Intestinal Intraepithelial Neoplasia

Postaxial Acrofacial Dysostosis

Miller Syndrome	POADS
Genee-Wiedemann Syndrome	Postaxial Acrodysostosis
Genee-Wiedemann Acrofacial Dysostosis	Acrofacial Dysostosis, Genee-Wiedmann Type
Mandibulfacial Dysostosis With Postaxial Limb Anomalies	Gwafd
Poads Syndrome	Postaxial Acrofacial Dysostosis Syndrome
Wildervanck-Smith Syndrome	Acrofacial Dysostosis, Genee-Wiedemann Type
Mandibulofacial Dysostosis With Postaxial Limb Anomalies	Genée-Wiedemann Syndrome
Chromosome 11p Deletion Syndrome

Intestinal Impaction

Congenital Diarrhea

Microvillus Inclusion Disease

Congenital Microvillous Atrophy	Intractable Diarrhea Of Infancy
Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities	Davidson Disease
Microvillous Inclusion Disease	Congenital Microvillus Atrophy
Mvid	Diarrhea 2 With Microvillus Atrophy
Mvd	Congenital Familial Protracted Diarrhea
Davidson'S Disease	Familial Enteropathy, Microvillus
Microvillus Atrophy, Congenital	Congenital Enteropathy
Familial Protracted Enteropathy	Microvillous Atrophy
Microvillus Atrophy With Diarrhea 2	Idi

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy	Fshd
Landouzy-Dejerine Muscular Dystrophy	Muscular Dystrophy, Facioscapulohumeral
FSHD1	Fshd1a
Muscular Dystrophy, Facioscapulohumeral, Type 1a	Facioscapulohumeral Muscular Dystrophy Type 1a
Fsh Muscular Dystrophy	Facioscapulohumeral Muscular Dystrophy 1a
Facioscapulohumeral Atrophy	Facioscapulohumeral Myopathy
Muscular Dystrophy, Facioscapulohumeral, Type 1	Facioscapulohumeral Muscular Dystrophy Type 1
Landouzy Dejerine Muscular Dystrophy	Muscular Dystrophy, Landouzy-Dejerine
Fshmd1a	Facio-Scapulo-Humeral Dystrophy
Facioscapulohumeral Type Progressive Muscular Dystrophy	Facioscapuloperoneal Muscular Dystrophy
Facioscapulohumeral Dystrophy	Fsh Dystrophy
Landouzy-Dejerine Dystrophy	Landouzy-Dejerine Myopathy
Fmd	Facioscapulohumeral Muscular Dystrophy-1a
Muscular Dystrophy Facioscapulohumeral	Dystrophy, Muscular, Facioscapulohumeral
Dystrophy, Muscular, Facioscapulohumeral, Type 1	Landouzy-Dejerine Disease
Landouzy-Déjerine Atrophy	Facioscapulohumeral Muscle Dystrophy
Fmd - [Facioscapulohumeral Muscular Dystrophy]	Fsh - [Facioscapulohumeral Muscular Dystrophy]
Fshd - [Facioscapulohumeral Muscular Dystrophy]	Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy
Landouzy-Déjérine Muscular Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105028	Tenidap	Inhibitor	99.32%	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149276	SLC26A3-IN-2		≥98.0%	Unkown
HY-159706	S9-A13	Inhibitor	/	Unkown
HY-105028S	Tenidap-d3	Inhibitor	/	Unkown
HY-128361	SLC26A3-IN-3	Inhibitor	/	Unkown
HY-149802	SLC26A3-IN-1		/	Unkown
HY-RS13137	SLC26A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-105028A	Tenidap sodium	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC26A3	VGNC	VGNC:46323
Macaca mulatta	SLC26A3	VGNC	VGNC:108438
Rattus norvegicus	SLC26A3	RGD	RGD:620623
Felis catus	SLC26A3	VGNC	VGNC:65284
Bos taurus	SLC26A3	VGNC	VGNC:34778
Mus musculus	SLC26A3	MGD	MGI:107181

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