Nos2 - nitric oxide synthase 2, inducible Gene

Mus musculus

Also known as iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS

Gene ID: 18126 | Gene type: protein coding

About Nos2

Chromosome 11: 78,811,613-78,851,080 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 136 phenotypes. Biased expression in large intestine adult (RPKM 3.6), ovary adult (RPKM 13.) and 6 other tissues.

Summary

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nos2 Products(3)

mRNA	Protein	Name
NM_010927.4	NP_035057.1	nitric oxide synthase, inducible isoform a
NM_001313922.1	NP_001300851.1	nitric oxide synthase, inducible isoform b
NM_001313921.1	NP_001300850.1	nitric oxide synthase, inducible isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables FMN binding	IDA IDA: Inferred from direct assay	1383204	MGI
enables arginine binding	IDA IDA: Inferred from direct assay	9271491	MGI
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	1383204	MGI
enables heme binding	IDA IDA: Inferred from direct assay	1383204	MGI
enables nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	1383204	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12855682	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9271491	MGI
enables tetrahydrobiopterin binding	IDA IDA: Inferred from direct assay	9271491	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in arginine catabolic process	IDA IDA: Inferred from direct assay	1383204	MGI
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within cellular response to type II interferon	IDA IDA: Inferred from direct assay	18025219	MGI
acts upstream of or within cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	24486487	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	22073225	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	12933833	MGI
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	12085352	MGI
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	18003616	MGI
involved in nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	1383204	MGI
NOT acts upstream of or within ovulation from ovarian follicle	IMP IMP: Inferred from mutant phenotype	11779605	MGI
involved in peptidyl-cysteine S-nitrosylation	IDA IDA: Inferred from direct assay	16373578	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	11606502	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	12960352	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	22073225	MGI
acts upstream of or within superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	12933833	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	12960352	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11732991	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12960352	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nos2 Protein Structure

NOS_oxygenase_euk

Flavodoxin_1

FNR_like

0
200
400
600
800
1000
1144 a.a.

Protein Preferred Names

Protein Names

nitric oxide synthase, inducible

NOS type II	inducible NO synthase
inducible NOS	inducible nitric oxide synthase
macrophage NOS	nitric oxide synthase 2, inducible, macrophage
peptidyl-cysteine S-nitrosylase NOS2

Nos2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nos2	P29477	Rela	Mus musculus	Q04207	Anti Tag CoIP	21464294
Intra	Nos2	P29477	Rela	Mus musculus	Q04207	Anti Bait CoIP	21464294

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18732A	L-NMMA acetate	Inhibitor	≥99.0%	Phase 4

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12124	BBS-4	Inhibitor	99.51%	Unkown
HY-RS09438	Nos2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-152213	BET-IN-13	Inhibitor	/	Unkown
HY-RS09437	NOS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09439	NOS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nos2	NCBI	NCBI:4843

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