1. Gene
  2. DRD4 - dopamine receptor D4 Gene

DRD4 - dopamine receptor D4 Gene

Homo sapiens

Also known as D4DR

Gene ID: 1815 | Gene type: protein coding

About DRD4

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:637,269-640,706 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 247 orthologues, 25 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

This gene encodes the D4 subtype of the Dopamine Receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

DRD4 Products(1)

mRNA Protein Name
NM_000797.4 NP_000788.2 D(4) dopamine receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH3 domain binding IDA
IDA: Inferred from direct assay
9843378 GOA
enables dopamine binding IDA
IDA: Inferred from direct assay
1319557 GOA
enables dopamine neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
8413587 GOA
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
IDA: Inferred from direct assay
1840645 GOA
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go IMP
IMP: Inferred from mutant phenotype
27659709 GOA
enables epinephrine binding IDA
IDA: Inferred from direct assay
9003072 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21184734 GOA
enables norepinephrine binding IDA
IDA: Inferred from direct assay
9003072 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12297500 GOA
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
7512953 GOA
involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27659709 GOA
involved in arachidonate secretion IDA
IDA: Inferred from direct assay
7512953 GOA
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
7921596 GOA
involved in negative regulation of protein secretion IDA
IDA: Inferred from direct assay
16839358 GOA
involved in phospholipase C-activating dopamine receptor signaling pathway IDA
IDA: Inferred from direct assay
1840645 GOA
acts upstream of positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
9843378 GOA
involved in response to histamine IDA
IDA: Inferred from direct assay
16839358 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
7512953 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8413587 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRD4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (51 - 400)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
Protein Preferred Names Protein Names

D(4) dopamine receptor

D(2C) dopamine receptor

dopamine D4 receptor

seven transmembrane helix receptor

DRD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DRD4 P21917 NECAB3 Homo sapiens Q96P71-2
Validated Y2H
32814053
Intra
DRD4 P21917 NECAB3 Homo sapiens Q96P71-2
Y2H Array
32814053
Intra
DRD4 P21917 NECAB3 Homo sapiens Q96P71-2
Y2H Pooling
32814053
Intra
DRD4 P21917 METAP2 Homo sapiens P50579
Y2H Array
32814053
Intra
DRD4 P21917 METAP2 Homo sapiens P50579
Y2H Pooling
32814053
Intra
DRD4 P21917 METAP2 Homo sapiens P50579
Validated Y2H
32814053
Intra
DRD4 P21917 DRD4 Homo sapiens P21917
Anti Tag CoIP
21320289
Intra
DRD4 P21917 ADRA1B Homo sapiens P35368
BRET
22723743
Intra
DRD4 P21917 DRD4 Homo sapiens P21917
BRET
21184734
Intra
DRD4 P21917 ADRA1B Homo sapiens P35368
Anti Bait CoIP
22723743
Intra
DRD4 P21917 DRD4 Homo sapiens P21917
BRET
21320289
Intra
DRD4 P21917 ADRB1 Homo sapiens P08588
Anti Bait CoIP
22723743
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Exhibitionism
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette

Drug Dependence
Cannabis Abuse

Marijuana Abuse

Delusional Disorder

Persistent Delusional Disorders

Delusional Perception

Induced Delusional Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Cyclothymic Disorder

Cyclothymia

Cycloid Personality

Cyclothymic Personality

Affective Personality Disorder

Cyclothymic Personality Disorder

Cycloid Personality Disorder

Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders

Conduct Disorder
Antisocial Personality Disorder

Dissocial Personality Disorder

Asocial Personality

Psychopath.Personality

Psychopathic Personality

Psychopathic Personality Disorder

Sociopathic Personality

Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction

Autonomic Nervous System Disorders

Autonomic Nervous System Disorder

Autonomic Nervous System Diseases

Abnormality Of The Autonomic Nervous System

Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis

Paraphilia Disorder

Paraphilia

Paraphilias

Separation Anxiety Disorder

Separation Anxiety Disorder Of Childhood

Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Bestiality

Zoophilia

Heroin Dependence
Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To

Dyslexia
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Bulimia Nervosa

Bulimia

Bulimia Nervosa, Susceptibility To

Binge Eating Disorder

BULN

Bn

Hyperorexia Nervosa

Bulimia Nervosa 2

BULN2

Susceptibility To Bulimia Nervosa

Bulimia Nervosa, Susceptibility To, Type 2

Bn - [Bulimia Nervosa]

Bulimia Nos

Bulimic

Bingeing

Binge Overeating

Bouts Of Overeating

Episodes Of Overeating

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome

Oppositional Defiant Disorder

Disorder

Oppositional Defiance

Behavioural Disorder

Oppositional Defiance

Disruptive Mood Dysregulation Disorder

Pathological Gambling

Compulsive Gambling

Gambling

Gambling, Pathological

Addiction

Betting

Addiction

Gambling

Betting

Pathological

Gambling

Dependence

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To

ANON

Anorexia Nervosa, Susceptibility To, 1

An

Anorexia Nervosa 1

An - [Anorexia Nervosa]

Dysthymic Disorder

Dysthymia

Chronic Depressive Disorder

Chronic Depression

Depressive Personality

Depressive Personality Disorder

Persistent Depressive Disorder

Persistent Depression

Specific Developmental Disorder
Mood Disorder

Mood Disorders

Episodic Mood Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Mental Depression

Depression

Depressive Disorder

Substance Dependence
Personality Disorder

Personality Disorders

Character Disorder

Personality

Specific Personality Disorders

Enduring Personality Change After Psychiatric Illness

Schizoaffective Disorder

Schizo-Affective Psychosis

Schizo-Affective Type Schizophrenia

Schizoaffective Psychosis

Schizoaffective Schizophrenia

Schizophrenia, Schizo-Affective Type

Schizophreniform Psychosis, Affective Type

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Novelty Seeking Personality Trait

Novelty Seeking, Personality Trait

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Avoidant Personality Disorder

Anxious Personality Disorder

Personality Disorders

Cholestasis, Intrahepatic, Of Pregnancy 3

ICP3

Cholestasis, Intrahepatic, Of Pregnancy, 3

Intrahepatic Cholestasis Of Pregnancy 3

Pregnancy Related Cholestasis 3

Cholestasis Of Pregnancy, Intrahepatic 3

Cholestasis, Intrahepatic, Of Pregnancy, Type 3

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos

Migraine Without Aura

Common Migraine

Migraine With Or Without Aura, Susceptibility To

Migraine Without Aura, Susceptibility To

Acute Migraine Without Aura

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Tic Disorder

Tics

Behavioral Tic

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DRD4 RGD RGD:2522
Mus musculus DRD4 MGD MGI:94926
Macaca mulatta DRD4 VGNC VGNC:100919