Nsf - N-ethylmaleimide sensitive fusion protein Gene

Mus musculus

Also known as SKD2

Gene ID: 18195 | Gene type: protein coding

About Nsf

Summary

Enables ATP hydrolysis activity; protein kinase binding activity; and syntaxin-1 binding activity. Acts upstream of or within potassium ion transport. Located in myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase). [provided by Alliance of Genome Resources, Apr 2022]

Nsf Products(1)

mRNA	Protein	Name
NM_008740.4	NP_032766.2	vesicle-fusing ATPase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	12832401	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15322554	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21307259	MGI
enables syntaxin binding	IDA IDA: Inferred from direct assay	14755058	MGI
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	21307259	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within potassium ion transport	IDA IDA: Inferred from direct assay	8082782	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-fusing ATPase

N-ethylmaleimide sensitive factor	NEM-sensitive fusion protein
suppressor of K(+) transport growth defect 2	vesicular-fusion protein NSF

Nsf Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nsf	P46460	Lrrk2	Mus musculus	Q5S006	Anti Bait CoIP	21307259
Intra	Nsf	P46460	Dlg4	Mus musculus	Q62108	Anti Bait CoIP	19455133
Intra	Nsf	P46460	Musk	Mus musculus	Q61006-3	ELISA	18272689
Intra	Nsf	P46460	Musk	Mus musculus	Q61006-3	Anti Tag CoIP	18272689
Intra	Nsf	P46460	Musk	Mus musculus	Q61006-3	Y2H	18272689
Intra	Nsf	P46460	Ptpn9	Mus musculus	O35239	Pull Down	15322554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1399A	Pep2m, myristoylated TFA	Inhibitor	99.77%	Unkown
HY-P4114	TAT-NSF700scr		95.17%	Unkown
HY-RS09591	NSF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P1399	Pep2m, myristoylated	Inhibitor	/	Unkown
HY-P4110	TAT-NSF222 Fusion Peptide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nsf	NCBI	NCBI:4905
Canis familiaris	Nsf	NCBI	NCBI:490921
Macaca fascicularis	Nsf	NCBI	NCBI:101866905
Susscrofa domestica	Nsf	NCBI
Rattus norvegicus	Nsf	NCBI	NCBI:60355

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