Nsf - N-ethylmaleimide sensitive factor, vesicle fusing ATPase Gene

Rattus norvegicus

Gene ID: 60355 | Gene type: protein coding

About Nsf

Summary

Enables several functions, including ATP hydrolysis activity; ATP-dependent protein binding activity; and signaling receptor binding activity. Involved in several processes, including protein transport; protein-containing complex disassembly; and regulation of vesicle-mediated transport. Located in Golgi stack; dendritic shaft; and postsynaptic density. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase). [provided by Alliance of Genome Resources, Apr 2022]

Nsf Products(1)

mRNA	Protein	Name
NM_021748.2	NP_068516.2	vesicle-fusing ATPase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	11062069	RGD
enables ATP-dependent protein binding	IPI IPI: Inferred from physical interaction	11062069	RGD
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	20623535	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	12130635	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9697854	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	20802490	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11931741	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	11062069	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	21807099	RGD
involved in protein-containing complex disassembly	IDA IDA: Inferred from direct assay	11931741	RGD
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	11245593	RGD
involved in regulation of receptor internalization	IDA IDA: Inferred from direct assay	11931741	RGD
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	11245593	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	11461150	RGD
located in Golgi stack	IDA IDA: Inferred from direct assay	11062069	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	1041498	RGD
is active in postsynaptic specialization, intracellular component	IDA IDA: Inferred from direct assay	11461150	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-fusing ATPase

N-ethylmaleimide-sensitive factor	N-ethylmaleimide-sensitive fusion protein
NEM-sensitive fusion protein	vesicular-fusion protein NSF

Nsf Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nsf	Q9QUL6	Gria2	Rattus norvegicus	P19491	Y2H	9697854
Intra	Nsf	Q9QUL6	Gria2	Rattus norvegicus	P19491	Pull Down	9697854

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1399A	Pep2m, myristoylated TFA	Inhibitor	99.77%	Unkown
HY-P4114	TAT-NSF700scr		95.17%	Unkown
HY-P1399	Pep2m, myristoylated	Inhibitor	/	Unkown
HY-P4110	TAT-NSF222 Fusion Peptide	Inhibitor	/	Unkown
HY-RS09591	NSF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nsf	NCBI	NCBI:4905
Canis familiaris	Nsf	NCBI	NCBI:490921
Macaca fascicularis	Nsf	NCBI	NCBI:101866905
Mus musculus	Nsf	NCBI	NCBI:18195
Susscrofa domestica	Nsf	NCBI

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