Sqstm1 - sequestosome 1 Gene

Mus musculus

Also known as Osi; p62; A170; STAP; OSF-6; STONE14

Gene ID: 18412 | Gene type: protein coding

About Sqstm1

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation; energy homeostasis; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2022]

Sqstm1 Products(2)

mRNA	Protein	Name
NM_001290769.1	NP_001277698.1	sequestosome-1 isoform 2
NM_011018.3	NP_035148.1	sequestosome-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	16252010	MGI
enables identical protein binding	IDA IDA: Inferred from direct assay	21220506	MGI
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	19004011	MGI
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	33397898	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	33397898	MGI
enables ubiquitin-modified protein reader activity	IDA IDA: Inferred from direct assay	25723488	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aggrephagy	IDA IDA: Inferred from direct assay	25723488	MGI
involved in autophagy	IDA IDA: Inferred from direct assay	20173742	MGI
involved in brown fat cell proliferation	IMP IMP: Inferred from mutant phenotype	32385399	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	32385399	MGI
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	20173742	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24035364	MGI
involved in non-membrane-bounded organelle assembly	IDA IDA: Inferred from direct assay	33397898	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	19004011	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19004011	MGI
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	32385399	MGI
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	32385399	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	32385399	MGI
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	32385399	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24035364	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in aggresome	IDA IDA: Inferred from direct assay	22792322	MGI
located in autolysosome	IDA IDA: Inferred from direct assay	26284655	MGI
located in autophagosome	IDA IDA: Inferred from direct assay	24713655	MGI
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	33397898	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	32047033	MGI
located in phagophore assembly site	IDA IDA: Inferred from direct assay	21220506	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	22033522	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sequestosome-1

oxidative stress induced

ubiquitin-binding protein p62

Sqstm1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Sqstm1	Q64337	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Tag CoIP	19250911
Intra	Sqstm1	Q64337	Keap1	Mus musculus	Q9Z2X8	Pull Down	20173742
Intra	Sqstm1	Q64337	Keap1	Mus musculus	Q9Z2X8	Anti Tag CoIP	20173742
Cross	Sqstm1	Q64337	KEAP1	Homo sapiens	Q14145	Anti Tag CoIP	20173742

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112698	CA-5f		99.14%	Unkown
HY-117469	Triptohypol C		95.44%	Unkown
HY-152100	CUR5g	Inhibitor	98.69%	Unkown
HY-RS13745	SQSTM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sqstm1	NCBI	NCBI:8878

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