Keap1 - kelch-like ECH-associated protein 1 Gene

Mus musculus

Also known as INRF2; mKIAA0132

Gene ID: 50868 | Gene type: protein coding

About Keap1

Chromosome 9: 21,141,026-21,150,657 reverse strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 189 orthologues, 54 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 41.2), adrenal adult (RPKM 36.) and 28 other tissues.

Summary

Enables disordered domain specific binding activity and identical protein binding activity. Involved in cellular protein metabolic process; cellular response to oxidative stress; and regulation of Autophagy. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin Ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder Cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Keap1 Products(4)

mRNA	Protein	Name
NM_016679.4	NP_057888.1	kelch-like ECH-associated protein 1
NM_001110306.1	NP_001103776.1	kelch-like ECH-associated protein 1
NM_001110305.1	NP_001103775.1	kelch-like ECH-associated protein 1
NM_001110307.1	NP_001103777.1	kelch-like ECH-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	16581765	MGI
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	16581765	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20133743	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12151510	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to interleukin-4	IDA IDA: Inferred from direct assay	9798653	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	15282312	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15087497	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15282312	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15087497	MGI
involved in regulation of autophagy	IDA IDA: Inferred from direct assay	20173742	MGI
acts upstream of or within regulation of epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	15087497	MGI
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15282312	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	15282312	MGI
located in actin filament	IDA IDA: Inferred from direct assay	14764898	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15367669	MGI
located in cytoplasm	IPI IPI: Inferred from physical interaction	14517290	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	14517290	MGI
located in inclusion body	IDA IDA: Inferred from direct assay	20173742	MGI
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	16581765	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Keap1 Protein Structure

BTB_POZ_KLHL19_KEAP1

PHA03098

Kelch

0
100
200
300
400
500
624 a.a.

Protein Preferred Names

Protein Names

kelch-like ECH-associated protein 1

NRF2 cytosolic inhibitor	cytosolic inhibitor of Nrf2
ring canal protein

Keap1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Keap1	Q9Z2X8	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20173742
Intra	Keap1	Q9Z2X8	Nfe2l2	Mus musculus	Q60795	ITC	24366543
Intra	Keap1	Q9Z2X8	Nfe2l2	Mus musculus	Q60795	X-Ray Diffraction	24366543
Intra	Keap1	Q9Z2X8	Nfe2l2	Mus musculus	Q60795	Pull Down	31169361
Intra	Keap1	Q9Z2X8	Nfe2l2	Mus musculus	Q60795	Pull Down	24366543
Intra	Keap1	Q9Z2X8	Nfe2l2	Mus musculus	Q60795	TSA	24366543
Intra	Keap1	Q9Z2X8	Nfe2l2	Mus musculus	Q60795	SPR	24366543
Intra	Keap1	Q9Z2X8	Sqstm1	Mus musculus	Q64337	X-Ray Diffraction	20173742
Intra	Keap1	Q9Z2X8	Sqstm1	Mus musculus	Q64337	ITC	20173742
Intra	Keap1	Q9Z2X8	Sqstm1	Mus musculus	Q64337	Anti Tag CoIP	20173742
Intra	Keap1	Q9Z2X8	Sqstm1	Mus musculus	Q64337	Pull Down	20173742

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0005	Curcumin		98.84%	Phase 4
HY-13755	Sulforaphane		99.75%	Phase 4

Pre-clinical Phase

Bioactive Molecules (68)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100218A	RSL3		99.90%	Unkown
HY-112675	4-Octyl itaconate	Activator	99.98%	Unkown
HY-19543	Brusatol		99.89%	Unkown
HY-101140	KI696	Inhibitor	99.26%	Unkown
HY-110258	ML334	Activator	99.76%	Unkown
HY-134205A	CBR-470-1	Activator	98.03%	Unkown
HY-111126	K67	Activator	98.43%	Unkown
HY-145879	Nrf2 activator-2	Activator	98.92%	Unkown
HY-13755A	(R)-Sulforaphane		99.48%	Unkown
HY-120371	CPUY192018	Inhibitor	98.99%	Unkown
HY-W009731	Dibenzoylmethane	Activator	≥98.0%	Unkown
HY-110275	RA839		98.90%	Unkown
HY-131592	Tricetin		99.19%	Unkown
HY-139047	SW157765	Inhibitor	98.67%	Unkown
HY-149508	Nrf2-IN-3	Inhibitor	99.19%	Unkown
HY-B0854	Mancozeb		/	Unkown
HY-101140A	KI696 isomer	Inhibitor	99.32%	Unkown
HY-100218C	(1R,3R)-RSL3	Control	99.52%	Unkown
HY-P1328	TAT-14	Activator	99.66%	Unkown
HY-122054A	BPK-29 hydrochloride	Inhibitor	98.28%	Unkown
HY-149010	NXPZ-2	Inhibitor	/	Unkown
HY-150579	Keap1-Nrf2-IN-13	Inhibitor	96.77%	Unkown
HY-110258B	(R,S,R)-ML334		98.57%	Unkown
HY-139620A	MS83 epimer 1		98.36%	Unkown
HY-122054	BPK-29	Inhibitor	99.4%	Unkown
HY-121523	MIND4-17	Activator	99.93%	Unkown
HY-139620	MS83	Chemical	/	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-151362	Keap1-Nrf2-IN-14	Inhibitor	/	Unkown
HY-162152	biKEAP1	Inhibitor	/	Unkown
HY-RS07230	KEAP1 Human Pre-designed siRNA Set A		/	Unkown
HY-112675S	4-Octyl itaconate-13C5-1		/	Unkown
HY-124834	Nrf2 activator-10		/	Unkown
HY-124941	7-Deacetylgedunin	Activator	/	Unkown
HY-139862	Keap1-Nrf2-IN-3	Inhibitor	/	Unkown
HY-141439	TBE 31	Activator	/	Unkown
HY-143892	Keap1-Nrf2-IN-5	Inhibitor	/	Unkown
HY-143893	Keap1-Nrf2-IN-6	Inhibitor	/	Unkown
HY-144099	Keap1-Nrf2-IN-4		/	Unkown
HY-146577	Keap1-Nrf2-IN-7	Inhibitor	/	Unkown
HY-146578	Keap1-Nrf2-IN-8	Inhibitor	/	Unkown
HY-147548	Keap1-Nrf2-IN-10	Inducer	/	Unkown
HY-147924	Keap1-Nrf2-IN-11	Inhibitor	/	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-150578	Keap1-Nrf2-IN-12	Inhibitor	/	Unkown
HY-155997	Anti-inflammatory agent 56	Inhibitor	/	Unkown
HY-156065	S217879	Activator	/	Unkown
HY-157928	Keap1-Nrf2-IN-18	Inhibitor	/	Unkown
HY-157929	Keap1-Nrf2-IN-19	Inhibitor	/	Unkown
HY-159495	Keap1-Nrf2-IN-21		/	Unkown
HY-160876	BC-1901S	Activator	/	Unkown
HY-161643	S21-1011		/	Unkown
HY-168065	Keap1-Nrf2-IN-22	Inhibitor	/	Unkown
HY-168161	Keap1-Nrf2-IN-23	Inhibitor	/	Unkown
HY-168526	Keap1-Nrf2-IN-24	Inhibitor	/	Unkown
HY-168640	RIP3 activator 1		/	Unkown
HY-169315	Nrf2 activator 17	Activator	/	Unkown
HY-N10313	Dehydrobruceine B		/	Unkown
HY-N8160	Dehydrocurdione		/	Unkown
HY-P10530	Nrf2 (69-84)		/	Unkown
HY-P1328A	TAT-14 TFA	Activator	/	Unkown
HY-P5480	Keap1-Nrf2-IN-16		/	Unkown
HY-P5909	Keap1-Nrf2 probe		/	Unkown
HY-P5909F	FITC-labelled Keap1-Nrf2 probe		/	Unkown
HY-RS07231	Keap1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07232	Keap1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-162096	Keap1-Nrf2-IN-17	Inhibitor	/	Unkown
HY-W505984	TPNA10168	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Keap1	NCBI	NCBI:9817

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