2. Gene
  3. Pak3 - p21 (RAC1) activated kinase 3 Gene

Pak3 - p21 (RAC1) activated kinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Stk4; PAK-3; Pak65beta; Pak65alpha

Gene ID: 18481 | Gene type: protein coding

About Pak3

Chromosome X: 142,301,587-142,580,792 forward strand.GRCm39:CM001013.3

This gene has 10 transcripts (splice variants), 213 orthologues, 35 paralogues and is associated with 7 phenotypes. Biased expression in CNS E18 (RPKM 8.), whole brain E14.5 (RPKM 6.4) and 8 other tissues.

Summary

Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis and dendritic spine morphogenesis. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pak3 Products(5)

mRNA Protein Name
NM_001195046.1 NP_001181975.1 serine/threonine-protein kinase PAK 3 isoform A
NM_001195049.1 NP_001181978.1 serine/threonine-protein kinase PAK 3 isoform D
NM_001195048.1 NP_001181977.1 serine/threonine-protein kinase PAK 3 isoform C
NM_001195047.1 NP_001181976.1 serine/threonine-protein kinase PAK 3 isoform B
NM_008778.3 NP_032804.2 serine/threonine-protein kinase PAK 3 isoform D

Pak3 Protein Structure

PBD

PBD: pfam00786 (68 - 140)

STKc_PAK3

STKc_PAK3: cd06656 (262 - 558)

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  • 559 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 3

CDC42/RAC effector kinase PAK-B

beta-PAK

p21 protein (Cdc42/Rac)-activated kinase 3

p21-activated kinase 3

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.84% Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15542A FRAX597 Inhibitor 99.79% Unkown
HY-15542B FRAX486 Inhibitor 98.01% Unkown
HY-143490 PAK4-IN-2 Inhibitor 99.78% Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak3 NCBI NCBI:5063