Pak3 - p21 (RAC1) activated kinase 3 Gene

Mus musculus

Also known as Stk4; PAK-3; Pak65beta; Pak65alpha

Gene ID: 18481 | Gene type: protein coding

About Pak3

Chromosome X: 142,301,587-142,580,792 forward strand.GRCm39:CM001013.3

This gene has 10 transcripts (splice variants), 213 orthologues, 35 paralogues and is associated with 7 phenotypes. Biased expression in CNS E18 (RPKM 8.), whole brain E14.5 (RPKM 6.4) and 8 other tissues.

Summary

Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis and dendritic spine morphogenesis. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pak3 Products(5)

mRNA	Protein	Name
NM_001195046.1	NP_001181975.1	serine/threonine-protein kinase PAK 3 isoform A
NM_001195049.1	NP_001181978.1	serine/threonine-protein kinase PAK 3 isoform D
NM_001195048.1	NP_001181977.1	serine/threonine-protein kinase PAK 3 isoform C
NM_001195047.1	NP_001181976.1	serine/threonine-protein kinase PAK 3 isoform B
NM_008778.3	NP_032804.2	serine/threonine-protein kinase PAK 3 isoform D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7493928	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	23509247	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	10445846	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	21115725	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	23509247	MGI
involved in dendrite development	IMP IMP: Inferred from mutant phenotype	21115725	MGI
acts upstream of or within dendritic spine development	IGI IGI: Inferred from genetic interaction	23509247	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	25851601	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	25851601	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	25851601	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15182717	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	15182717	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25851601	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	15182717	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	15182717	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak3 Protein Structure

PBD

STKc_PAK3

0
100
200
300
400
500
559 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 3

CDC42/RAC effector kinase PAK-B	beta-PAK
p21 protein (Cdc42/Rac)-activated kinase 3	p21-activated kinase 3

Pak3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Pak3	Q61036	CDC42	Homo sapiens	P60953	Filter Binding	7493928
Cross	Pak3	Q61036	CDC42	Homo sapiens	P60953	Solid Phase Assay	23022564

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Phase 1
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15542A	FRAX597	Inhibitor	99.36%	Unkown
HY-15542B	FRAX486	Inhibitor	98.01%	Unkown
HY-143490	PAK4-IN-2	Inhibitor	99.78%	Unkown
HY-146786	ZMF-10	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak3	NCBI	NCBI:5063

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