CDC42 - cell division cycle 42 Gene

Homo sapiens

Also known as TKS; G25K; CDC42Hs

Gene ID: 998 | Gene type: protein coding

About CDC42

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,052,709-22,101,360 (from NCBI)

This gene has 24 transcripts (splice variants), 237 orthologues, 22 paralogues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 88.8), colon (RPKM 72.7) and 25 other tissues.

Summary

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae CDC 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

CDC42 Products(3)

mRNA	Protein	Name
NM_001039802.2	NP_001034891.1	cell division control protein 42 homolog isoform 1 precursor
NM_001791.4	NP_001782.1	cell division control protein 42 homolog isoform 1 precursor
NM_044472.3	NP_426359.1	cell division control protein 42 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GBD domain binding	IPI IPI: Inferred from physical interaction	8625410	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	8625410	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	19787194	GOA
enables apolipoprotein A-I receptor binding	IPI IPI: Inferred from physical interaction	16443932	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9748241	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7493928	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	19039103	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8625410	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	12612085	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	21435037	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11035016	GOA
involved in actin filament organization	IMP IMP: Inferred from mutant phenotype	26465210	GOA
involved in cell junction assembly	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	22891260	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in negative regulation of protein-containing complex assembly	IPI IPI: Inferred from physical interaction	11584266	GOA
involved in neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	26465210	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	21435037	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20023705	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	8625410	GOA
involved in positive regulation of pseudopodium assembly	IDA IDA: Inferred from direct assay	11035016	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	8625410	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	11807099	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	26051942	GOA
involved in regulation of attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	15642749	GOA
involved in regulation of filopodium assembly	IDA IDA: Inferred from direct assay	14978216	GOA
involved in regulation of lamellipodium assembly	IGI IGI: Inferred from genetic interaction	8625410	GOA
involved in regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	8625410	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Golgi transport complex	IMP IMP: Inferred from mutant phenotype	16380373	GOA
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11260256	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in filopodium	IDA IDA: Inferred from direct assay	11035016	GOA
located in membrane	IDA IDA: Inferred from direct assay	11807099	GOA
located in membrane	IMP IMP: Inferred from mutant phenotype	22801373	GOA
located in midbody	IDA IDA: Inferred from direct assay	15642749	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	15642749	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	21048939	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	21048939	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11260256	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	20873783	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	15642749	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42 Protein Structure

Ras

0
100
191 a.a.

Protein Preferred Names

Protein Names

cell division control protein 42 homolog

G25K GTP-binding protein

Recombinant CDC42 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74258	CDC42 Protein, Human (GST)	P60953-2 (M1-C188)	≥95%

Related Diseases

Diseases

Alias

Takenouchi-Kosaki Syndrome

Macrothrombocytopenia-Lymphedema-Developmental Delay-Facial Dysmorphism-Camptodactyly Syndrome	TKS
Macrothrombocytopenia And Mental Retardation Syndrome

Neonatal-Onset Severe Multisystemic Autoinflammatory Disease With Increased Il18

Neonatal-Onset Autoinflammation-Cytopenia-Facial Dysmorphism Syndrome

Neonatal-Onset Severe Multisystemic Autoinflammatory Disease With Increased Interleukin 18

Immune System Disease

Abnormality Of The Immune System	Immune System And Disorders
Immune System Diseases

Wiskott-Aldrich Syndrome

WAS	Eczema-Thrombocytopenia-Immunodeficiency Syndrome
Immunodeficiency 2	Aldrich Syndrome
Imd2	Wiskott-Aldrich Syndrome 1
Was1	Wiskott Syndrome
Wiskott Aldrich Syndrome	Eczema Thrombocytopenia Immunodeficiency Syndrome
Imd 2

Temperature-Sensitive Lethal Mutation

Aarskog-Scott Syndrome

Aarskog Syndrome	Faciogenital Dysplasia
Faciodigitogenital Syndrome	AAS
Fgdy	X-Linked Aarskog Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic 16	Aarskog Syndrome, X-Linked
Intellectual Developmental Disorder, X-Linked Syndromic 16	Greig'S Syndrome
Aarskog Scott Syndrome	Aarskog Disease
Scott Aarskog Syndrome	Facio-Digito-Genital Dysplasia
Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder	Aarskog-Scott Syndrome ) Syndrome

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome	IMD73A
Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis	Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis
Rac 2 Deficiency

Charcot-Marie-Tooth Disease, Type 4h

Charcot-Marie-Tooth Disease Type 4h	CMT4H
Charcot-Marie-Tooth Neuropathy Type 4h	Charcot-Marie-Tooth Disease, Autosomal Recessive, Type 4h
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4h	Charcot-Marie-Tooth Neuropathy, Type 4h
Autosomal Recessive Charcot-Marie-Tooth Disease Type 4h	Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4h
Charcot-Marie-Tooth Disease 4h	Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4h

Unilateral Focal Polymicrogyria

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Pancytopenia

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Constipation

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Asbestos-Related Lung Carcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Spinal Cord Lipoma

Lipoma Of Spinal Cord

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Salmonellosis

Salmonella Infections

Salmonella Infection

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Parameningeal Embryonal Rhabdomyosarcoma

Prolapse Of Urethra

Urethrocele

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-12755	ML141		99.87%	Unkown
HY-112842	MBQ-167	Inhibitor	99.86%	Unkown
HY-12874	CASIN		99.89%	Unkown
HY-12810	EHop-016	Inhibitor	99.85%	Unkown
HY-111424	BDP9066	Inhibitor	98.36%	Unkown
HY-13963	ZCL278	Inhibitor	98.46%	Unkown
HY-N0710	alpha-Cyperone		99.80%	Unkown
HY-136379	CID44216842	Inhibitor	99.84%	Unkown
HY-10943	GNF-7	Inhibitor	99.70%	Unkown
HY-136383	AZA1		98.07%	Unkown
HY-113849	MLS-573151	Inhibitor	99.74%	Unkown
HY-115376	Z62954982	Inhibitor	≥99.0%	Unkown
HY-149464	ARN22089	Inhibitor	98.73%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-111424A	(R)-BDP9066		98.49%	Unkown
HY-116269	AZA197		98.28%	Unkown
HY-152095	PPI-GIT1/β-Pix interaction-IN-1	Inhibitor	99.01%	Unkown
HY-111423	BDP8900		/	Unkown
HY-149921	Antiangiogenic agent 3		/	Unkown
HY-161736	ARN25499	Inhibitor	/	Unkown
HY-RS02300	CDC42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02301	CDC42BPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02303	CDC42EP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02304	CDC42EP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02305	CDC42EP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-12646A	Rhosin		/	Unkown
HY-167828	ARN25062	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDC42	VGNC	VGNC:97251
Rattus norvegicus	CDC42	RGD	RGD:71043
Mus musculus	CDC42	MGD	MGI:106211
Macaca mulatta	CDC42	VGNC	VGNC:106339
Others	CDC42	NCBI