Ptpn11 - protein tyrosine phosphatase, non-receptor type 11 Gene

Mus musculus

Also known as Syp; Shp2; PTP1D; PTP2C; SAP-2; SHP-2; SH-PTP2; SH-PTP3; 2700084A17Rik

Gene ID: 19247 | Gene type: protein coding

About Ptpn11

Summary

Enables cell adhesion molecule binding activity; protein tyrosine Phosphatase activity; and signaling receptor binding activity. Involved in negative regulation of chondrocyte differentiation; positive regulation of cytokine production; and positive regulation of ossification. Acts upstream of or within several processes, including cell surface receptor signaling pathway; myeloid cell differentiation; and regulation of hormone secretion. Predicted to be located in several cellular components, including mitochondrion; plasma membrane raft; and stress fiber. Predicted to be part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study several diseases, including Noonan syndrome 1; Noonan syndrome with multiple lentigines; hepatocellular adenoma; intrinsic cardiomyopathy (multiple); and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine Phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn11 Products(2)

mRNA	Protein	Name
NM_001109992.1	NP_001103462.1	tyrosine-protein phosphatase non-receptor type 11 isoform b
NM_011202.3	NP_035332.1	tyrosine-protein phosphatase non-receptor type 11 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	19948503	MGI
enables non-membrane spanning protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	8955893	MGI
enables non-membrane spanning protein tyrosine phosphatase activity	IMP IMP: Inferred from mutant phenotype	15273746	MGI
enables peptide hormone receptor binding	IPI IPI: Inferred from physical interaction	15520383	MGI
enables phosphoprotein phosphatase activity	IMP IMP: Inferred from mutant phenotype	15273746	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7522233	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17954568	MGI
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	18827006	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	16885344	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Bergmann glial cell differentiation	IGI IGI: Inferred from genetic interaction	24431450	MGI
acts upstream of or within Bergmann glial cell differentiation	IMP IMP: Inferred from mutant phenotype	24431450	MGI
acts upstream of or within DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	12937170	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	12482708	MGI
acts upstream of or within cerebellar cortex formation	IGI IGI: Inferred from genetic interaction	24431450	MGI
acts upstream of or within cerebellar cortex formation	IMP IMP: Inferred from mutant phenotype	24431450	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18827006	MGI
involved in epidermal growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	10700187	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IGI IGI: Inferred from genetic interaction	24675817	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	24675817	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	15520383	MGI
acts upstream of or within integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23509158	MGI
acts upstream of or within intestinal epithelial cell migration	IMP IMP: Inferred from mutant phenotype	24675817	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within megakaryocyte development	IMP IMP: Inferred from mutant phenotype	23509158	MGI
acts upstream of or within microvillus organization	IMP IMP: Inferred from mutant phenotype	24675817	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within multicellular organismal reproductive process	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within negative regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	23509158	MGI
involved in negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	29644115	MGI
acts upstream of or within negative regulation of cortisol secretion	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within negative regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within negative regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12482708	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within platelet formation	IGI IGI: Inferred from genetic interaction	23509158	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	18827006	MGI
acts upstream of or within positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	15520383	MGI
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	17954568	MGI
involved in positive regulation of interleukin-6 production	IGI IGI: Inferred from genetic interaction	17954568	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	18827006	MGI
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	29644115	MGI
acts upstream of or within positive regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	15520383	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	17954568	MGI
acts upstream of or within regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12937170	MGI
acts upstream of or within regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	12937170	MGI
acts upstream of signal transduction	IMP IMP: Inferred from mutant phenotype	15520383	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	15520383	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	7523381	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 11

SH2 domain-containing protein tyrosine phosphatase-2

protein-tyrosine phosphatase SYP

Recombinant Ptpn11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74549	SHP-2 Protein, Mouse (HEK293, His)	P35235-2 (M1-R593)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101964	SPI-112	Inhibitor	97.06%	Unkown
HY-131132A	JAB-3068 hydrochloride	Inhibitor	98.88%	Unkown
HY-114460	SHP2-IN-1	Inhibitor	≥99.0%	Unkown
HY-131132	JAB-3068	Inhibitor	99.44%	Unkown
HY-120159	GS-493	Inhibitor	/	Unkown
HY-125259	SHP504	Inhibitor	/	Unkown
HY-RS11416	PTPN11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptpn11	NCBI	NCBI:5781

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