EFNA4 - ephrin A4 Gene

Homo sapiens

Also known as EFL4; EPLG4; LERK4; LERK-4

Gene ID: 1945 | Gene type: protein coding

About EFNA4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,063,740-155,069,553 (from NCBI)

This gene has 3 transcripts (splice variants), 149 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 7.7), colon (RPKM 6.4) and 23 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin that has been implicated in proliferation and metastasis of several types of cancers. [provided by RefSeq, May 2022]

EFNA4 Products(4)

mRNA	Protein	Name
NM_001406810.1	NP_001393739.1	ephrin-A4 isoform d
NM_005227.3	NP_005218.1	ephrin-A4 isoform a precursor
NM_182689.2	NP_872631.1	ephrin-A4 isoform b precursor
NM_182690.3	NP_872632.2	ephrin-A4 isoform c precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	11519828	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15777695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNA4 Protein Structure

Ephrin

0
100
201 a.a.

Protein Preferred Names

Protein Names

ephrin-A4

eph-related receptor tyrosine kinase ligand 4

EFNA4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EFNA4	P52798	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	EFNA4	P52798	EPHA4	Homo sapiens	P54764	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70376	Ephrin-A4/EFNA4 Protein, Human (HEK293, His)	P52798 (L26-G171)	≥95%
HY-P73010	Ephrin-A4/EFNA4 Protein, Human (HEK293, Fc)	P52798 (L26-G171)	≥95%

Related Diseases

Diseases

Alias

Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia	CFNS
Cfnd	Craniofrontonasal Dysostosis
Craniofrontonasal Dystosis	Dysplasia, Craniofrontonasal

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Muenke Syndrome

Muenke Nonsyndromic Coronal Craniosynostosis	Fgfr3-Related Craniosynostosis
Fgfr3-Associated Coronal Synostosis	Coronal Craniosynostosis
MNKES	Syndrome Of Coronal Craniosynostosis
MNKS	Fgfr3-Related Isolated Coronal Synostosis
Muenke Non-Syndromic Coronal Craniosynostosis

Saethre-Chotzen Syndrome

SCS	Acs3
Acs Iii	Chotzen Syndrome
Acrocephaly, Skull Asymmetry, And Mild Syndactyly	Acrocephalosyndactyly Type 3
Acrocephalosyndactyly, Type Iii	Acrocephalosyndactyly Type Iii
Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies	Auralcephalosyndactyly
Acs 3	Acrocephalo-Syndactyly, Type 3
Blepharophimosis,Epicanthus Inversus, And Ptosis 3	Aural Cephalosyndactyly
Kurczynski-Casperson Syndrome	Acrocephalosyndactyly Iii
Dysostosis Craniofacialis With Hypertelorism	Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies
Sakati Syndrome

Apert Syndrome

Acrocephalosyndactyly Type I	Acs1
Acrocephalosyndactylia	Acrocephalosyndactyly
Acs I	Apert-Crouzon Disease
Acrocephalosyndactyly Type 1	Acrocephalosyndactyly, Type I
Acs 1	Acrocephalo-Syndactyly Type 1
Syndactylic Oxycephaly	Apert'S Syndrome
Type I Acrocephalosyndactyly	APRS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04195	EFNA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111965	PF-06647263	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EFNA4	VGNC	VGNC:107870
Rattus norvegicus	EFNA4	RGD	RGD:1307808
Canis familiaris	EFNA4	VGNC	VGNC:40227
Mus musculus	EFNA4	MGD	MGI:106643
Bos taurus	EFNA4	VGNC	VGNC:28357
Others	EFNA4	NCBI

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