2. Gene
  3. TMEM147 - transmembrane protein 147 Gene

TMEM147 - transmembrane protein 147 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NEDFLPH; NIFIE14

Gene ID: 10430 | Gene type: protein coding

About TMEM147

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,545,626-35,547,526 (from NCBI)

This gene has 9 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in kidney (RPKM 36.7), thyroid (RPKM 34.7) and 25 other tissues.

Summary

Enables ribosome binding activity. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM147 Products(3)

mRNA Protein Name
NM_001242597.2 NP_001229526.1 transmembrane protein 147 isoform 2
NM_001242598.2 NP_001229527.1 transmembrane protein 147 isoform 3
NM_032635.4 NP_116024.1 transmembrane protein 147 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14667819 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
32820719 GOA
Biological Process GO Annotation Evidence Reference Source
involved in multi-pass transmembrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
36261522 GOA
involved in protein localization to nuclear inner membrane IDA
IDA: Inferred from direct assay
32694168 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
36044892 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
20538592 GOA
part of multi-pass translocon complex IDA
IDA: Inferred from direct assay
36261522 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
32694168 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20538592 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM147 Protein Structure

DUF2053

DUF2053: Predicted membrane protein (DUF2053) (2 - 158)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

transmembrane protein 147

protein NIFIE 14

TMEM147 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMEM147 Q9BVK8 SHISA3 Homo sapiens A0PJX4
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 SHISA3 Homo sapiens A0PJX4
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 LDLRAD1 Homo sapiens Q5T700
Y2H Array
31515488
Intra
TMEM147 Q9BVK8 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
25416956
Intra
TMEM147 Q9BVK8 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 DPM3 Homo sapiens Q9P2X0-2
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 DPM3 Homo sapiens Q9P2X0-2
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 DPM3 Homo sapiens Q9P2X0-2
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GPR61 Homo sapiens Q9BZJ8
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 GPR61 Homo sapiens Q9BZJ8
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GPR61 Homo sapiens Q9BZJ8
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 SLC12A7 Homo sapiens Q9Y666-2
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 SLC12A7 Homo sapiens Q9Y666-2
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 SLC12A7 Homo sapiens Q9Y666-2
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 ENPP4 Homo sapiens Q9Y6X5
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 ENPP4 Homo sapiens Q9Y6X5
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 ENPP4 Homo sapiens Q9Y6X5
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 LHFPL2 Homo sapiens Q6ZUX7
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 LHFPL2 Homo sapiens Q6ZUX7
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 IL3RA Homo sapiens P26951
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 IL3RA Homo sapiens P26951
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 IL3RA Homo sapiens P26951
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 RNF185 Homo sapiens Q96GF1
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 RNF185 Homo sapiens Q96GF1
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 CXCR2 Homo sapiens P25025
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 CXCR2 Homo sapiens P25025
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 PACC1 Homo sapiens Q9H813
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 PACC1 Homo sapiens Q9H813
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 PACC1 Homo sapiens Q9H813
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 EFNA4 Homo sapiens P52798
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 EFNA4 Homo sapiens P52798
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TACR1 Homo sapiens P25103
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TACR1 Homo sapiens P25103
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 CREB3L1 Homo sapiens Q96BA8
Y2H Array
31515488
Intra
TMEM147 Q9BVK8 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra
TMEM147 Q9BVK8 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra
TMEM147 Q9BVK8 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 F11R Homo sapiens Q9Y624
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 F11R Homo sapiens Q9Y624
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
TMEM147 Q9BVK8 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 TMEM252 Homo sapiens Q8N6L7
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 TMEM252 Homo sapiens Q8N6L7
Y2H Array
32296183
Intra
TMEM147 Q9BVK8 HTR2C Homo sapiens P28335
Y2H Prey Pooling
32296183
Intra
TMEM147 Q9BVK8 HTR2C Homo sapiens P28335
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Facial Dysmorphism, Absent Language, And Pseudo-Pelger-Huet Anomaly

NEDFLPH
Cystinosis

Cystine Storage Disease

Cystine Diathesis

Cystine Disease

Cystinoses

Protein Defect Of Cystin Transport

Cystin Transport, Protein Defect Of

Nephropathic Cystinosis

Protein Defect Of Cystine Transport
Dirofilariasis

Dirofilaria Infectious Disease

Infection By Dirofilaria
Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14670 TMEM147 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEM147 RGD RGD:1304706
Macaca mulatta TMEM147 VGNC VGNC:79849
Mus musculus TMEM147 MGD MGI:1915011
Bos taurus TMEM147 VGNC VGNC:35978
Felis catus TMEM147 VGNC VGNC:97662
Canis familiaris TMEM147 VGNC VGNC:47480