GGN - gametogenetin Gene

Homo sapiens

Gene ID: 199720 | Gene type: protein coding

About GGN

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,384,267-38,388,384 (from NCBI)

This gene has 5 transcripts (splice variants), 77 orthologues, 2 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 12.5).

Summary

This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

GGN Products(1)

mRNA	Protein	Name
NM_152657.4	NP_689870.3	gametogenetin

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gametogenetin

GGN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GGN	Q86UU5	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	GGN	Q86UU5	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	GGN	Q86UU5	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	GGN	Q86UU5	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	GGN	Q86UU5	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	GGN	Q86UU5	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	GGN	Q86UU5	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	GGN	Q86UU5	SH3KBP1	Homo sapiens	Q96B97	Validated Y2H	32296183
Intra	GGN	Q86UU5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	GGN	Q86UU5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	GGN	Q86UU5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GGN	Q86UU5	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	GGN	Q86UU5	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	GGN	Q86UU5	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	GGN	Q86UU5	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	GGN	Q86UU5	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	GGN	Q86UU5	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 69

SPGF69

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome	Del(17)(Q12)
Monosomy 17q12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05400	GGN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GGN	RGD	RGD:1306765
Bos taurus	GGN	VGNC	VGNC:29341
Mus musculus	GGN	MGD	MGI:2181461
Macaca mulatta	GGN	VGNC	VGNC:72740
Canis familiaris	GGN	VGNC	VGNC:41199
Others	GGN	NCBI

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