2. Gene
  3. CRTC2 - CREB regulated transcription coactivator 2 Gene

CRTC2 - CREB regulated transcription coactivator 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TORC2; TORC-2

Gene ID: 200186 | Gene type: protein coding

About CRTC2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,947,675-153,958,612 (from NCBI)

This gene has 10 transcripts (splice variants), 237 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 17.9), bone marrow (RPKM 17.3) and 25 other tissues.

Summary

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]

CRTC2 Products(1)

mRNA Protein Name
NM_181715.3 NP_859066.1 CREB-regulated transcription coactivator 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15454081 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRTC2 Protein Structure

TORC_N

TORC_N: Transducer of regulated CREB activity, N terminus (18 - 71)

TORC_M

TORC_M: Transducer of regulated CREB activity middle domain (168 - 320)

TORC_C

TORC_C: Transducer of regulated CREB activity, C terminus (615 - 692)

  • 0
  • 200
  • 400
  • 600
  • 693 a.a.
Protein Preferred Names Protein Names

CREB-regulated transcription coactivator 2

transducer of regulated cAMP response element-binding protein (CREB) 2

CRTC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CRTC2 Q53ET0 ATPAF2 Homo sapiens Q8N5M1
Validated Y2H
32296183
Intra CRTC2 Q53ET0 NONO Homo sapiens Q15233
Anti Bait CoIP
18077367
Intra CRTC2 Q53ET0 NONO Homo sapiens Q15233
FRET
18077367
Intra CRTC2 Q53ET0 YWHAB Homo sapiens P31946
CoIP
15324660
Intra CRTC2 Q53ET0 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra CRTC2 Q53ET0 SUFU Homo sapiens Q9UMX1
Validated Y2H
32296183
Intra CRTC2 Q53ET0 ATF6 Homo sapiens P18850
Anti Bait CoIP
19543265
Cross CRTC2 Q53ET0 bzlf1_ebvb9 Epstein-Barr virus P03206
Anti Tag CoIP
19164291
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Human T-Cell Leukemia Virus Type 1

Htlv-1

Human T Lymphotropic Virus Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03201 CRTC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CRTC2 RGD RGD:1308903
Macaca mulatta CRTC2 VGNC VGNC:71597
Bos taurus CRTC2 VGNC VGNC:97256
Mus musculus CRTC2 MGD MGI:1921593
Canis familiaris CRTC2 VGNC VGNC:53339
Felis catus CRTC2 VGNC VGNC:61193