1. Gene
  2. CDC23 - cell division cycle 23 Gene

CDC23 - cell division cycle 23 Gene

Homo sapiens

Also known as APC8; CUT23; ANAPC8

Gene ID: 8697 | Gene type: protein coding

About CDC23

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,187,650-138,213,323 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 12.7), testis (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

CDC23 Products(1)

mRNA Protein Name
NM_004661.4 NP_004652.2 cell division cycle protein 23 homolog
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
involved in mitotic cell cycle IDA
IDA: Inferred from direct assay
14657031 GOA
involved in mitotic metaphase chromosome alignment IDA
IDA: Inferred from direct assay
14657031 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in regulation of mitotic metaphase/anaphase transition IDA
IDA: Inferred from direct assay
9790767 GOA
Cellular Component GO Annotation Evidence Reference Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
14657031 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC23 Protein Structure

ANAPC8

ANAPC8: Anaphase promoting complex subunit 8 / Cdc23 (28 - 151)

TPR_1

TPR_1: Tetratricopeptide repeat (332 - 364)

TPR_11

TPR_11: TPR repeat (367 - 430)

TPR_1

TPR_1: Tetratricopeptide repeat (438 - 459)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

cell division cycle protein 23 homolog

anaphase-promoting complex subunit 8

CDC23 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CDC23 Q9UJX2 FLJ34048 Homo sapiens A4D1I3
Y2H Array
25416956
Intra CDC23 Q9UJX2 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra CDC23 Q9UJX2 PIH1D2 Homo sapiens Q8WWB5
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 PIH1D2 Homo sapiens Q8WWB5
Y2H Array
32296183
Intra CDC23 Q9UJX2 INPP5J Homo sapiens Q15735
Y2H Array
25416956
Intra CDC23 Q9UJX2 RBM15B Homo sapiens Q8NDT2-2
Y2H Array
25416956
Intra CDC23 Q9UJX2 SLC52A2 Homo sapiens Q9HAB3
Y2H Array
25416956
Intra CDC23 Q9UJX2 ANAPC13 Homo sapiens A8K3Z6
Validated Y2H
25416956
Intra CDC23 Q9UJX2 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra CDC23 Q9UJX2 FSBP Homo sapiens O95073
Validated Y2H
25416956
Intra CDC23 Q9UJX2 FSBP Homo sapiens O95073
Y2H Array
25416956
Intra CDC23 Q9UJX2 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra CDC23 Q9UJX2 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra CDC23 Q9UJX2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra CDC23 Q9UJX2 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra CDC23 Q9UJX2 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
25416956
Intra CDC23 Q9UJX2 CCDC24 Homo sapiens Q8N4L8
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra CDC23 Q9UJX2 FOXN1 Homo sapiens O15353
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 FOXN1 Homo sapiens O15353
Y2H Array
32296183
Intra CDC23 Q9UJX2 PROSER3 Homo sapiens Q2NL68
Y2H Array
32296183
Intra CDC23 Q9UJX2 PROSER3 Homo sapiens Q2NL68
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra CDC23 Q9UJX2 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 CRTC2 Homo sapiens Q53ET0
Y2H Array
32296183
Intra CDC23 Q9UJX2 CRTC2 Homo sapiens Q53ET0
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra CDC23 Q9UJX2 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra CDC23 Q9UJX2 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra CDC23 Q9UJX2 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra CDC23 Q9UJX2 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra CDC23 Q9UJX2 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra CDC23 Q9UJX2 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra CDC23 Q9UJX2 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra CDC23 Q9UJX2 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra CDC23 Q9UJX2 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra CDC23 Q9UJX2 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 APOL1 Homo sapiens O14791
Y2H Array
25416956
Intra CDC23 Q9UJX2 CERCAM Homo sapiens Q5T4B2
Y2H Array
32296183
Intra CDC23 Q9UJX2 CERCAM Homo sapiens Q5T4B2
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 DNAJB6 Homo sapiens O75190-2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 DNAJB6 Homo sapiens O75190-2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 DNAJB6 Homo sapiens O75190-2
Y2H Array
32814053
Intra CDC23 Q9UJX2 RBP3 Homo sapiens P10745
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 RBP3 Homo sapiens P10745
Y2H Array
32296183
Intra CDC23 Q9UJX2 EURL Homo sapiens Q9NYK6-3
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 EURL Homo sapiens Q9NYK6-3
Y2H Array
32296183
Intra CDC23 Q9UJX2 ANKRD11 Homo sapiens X5D778
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra CDC23 Q9UJX2 ANKRD11 Homo sapiens X5D778
Y2H Array
32296183
Intra CDC23 Q9UJX2 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra CDC23 Q9UJX2 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra CDC23 Q9UJX2 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra CDC23 Q9UJX2 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 NRBF2 Homo sapiens Q96F24
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 NRBF2 Homo sapiens Q96F24
Y2H Array
32296183
Intra CDC23 Q9UJX2 KCTD6 Homo sapiens Q8NC69
Y2H Array
32296183
Intra CDC23 Q9UJX2 KCTD6 Homo sapiens Q8NC69
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 KCTD6 Homo sapiens Q8NC69
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18
Y2H Array
32296183
Intra CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18
TAP
20360068
Intra CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18
Anti Tag CoIP
35271311
Intra CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 ANAPC13 Homo sapiens Q9BS18
Anti Tag CoIP
26496610
Intra CDC23 Q9UJX2 TOR1A Homo sapiens O14656-2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 TOR1A Homo sapiens O14656-2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 TOR1A Homo sapiens O14656-2
Y2H Array
32814053
Intra CDC23 Q9UJX2 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra CDC23 Q9UJX2 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra CDC23 Q9UJX2 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 RAC1 Homo sapiens P63000
Validated Y2H
25416956
Intra CDC23 Q9UJX2 RAC1 Homo sapiens P63000
Y2H Array
25416956
Intra CDC23 Q9UJX2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra CDC23 Q9UJX2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra CDC23 Q9UJX2 PRPF40A Homo sapiens O75400-2
Validated Y2H
32814053
Intra CDC23 Q9UJX2 PRPF40A Homo sapiens O75400-2
Y2H Array
32814053
Intra CDC23 Q9UJX2 PRPF40A Homo sapiens O75400-2
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 BCAS3 Homo sapiens Q9H6U6
Validated Y2H
25416956
Intra CDC23 Q9UJX2 INCA1 Homo sapiens Q0VD86
Y2H Array
25416956
Intra CDC23 Q9UJX2 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 ATXN10 Homo sapiens Q9UBB4
Validated Y2H
32814053
Intra CDC23 Q9UJX2 ATXN10 Homo sapiens Q9UBB4
Y2H Array
32814053
Intra CDC23 Q9UJX2 ATXN10 Homo sapiens Q9UBB4
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra CDC23 Q9UJX2 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra CDC23 Q9UJX2 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra CDC23 Q9UJX2 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Intra CDC23 Q9UJX2 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra CDC23 Q9UJX2 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra CDC23 Q9UJX2 TRIM27 Homo sapiens P14373
Y2H
21516116
Intra CDC23 Q9UJX2 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra CDC23 Q9UJX2 PHYH Homo sapiens O14832
Validated Y2H
32814053
Intra CDC23 Q9UJX2 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
Intra CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Pooling
16189514
Intra CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
Intra CDC23 Q9UJX2 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
25416956
Intra CDC23 Q9UJX2 CRACR2A Homo sapiens Q9BSW2
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 CRACR2A Homo sapiens Q9BSW2
Y2H Array
25416956
Intra CDC23 Q9UJX2 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra CDC23 Q9UJX2 RBPMS Homo sapiens Q93062
Y2H Pooling
16189514
Intra CDC23 Q9UJX2 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra CDC23 Q9UJX2 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 NUP54 Homo sapiens Q7Z3B4
Y2H Array
32296183
Intra CDC23 Q9UJX2 NUP54 Homo sapiens Q7Z3B4
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra CDC23 Q9UJX2 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 CBY2 Homo sapiens Q8NA61
Validated Y2H
25416956
Intra CDC23 Q9UJX2 CBY2 Homo sapiens Q8NA61
Y2H Array
25416956
Intra CDC23 Q9UJX2 BEGAIN Homo sapiens Q9BUH8
Y2H Array
32296183
Intra CDC23 Q9UJX2 BEGAIN Homo sapiens Q9BUH8
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra CDC23 Q9UJX2 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra CDC23 Q9UJX2 CYB5R2 Homo sapiens Q6BCY4
Validated Y2H
25416956
Intra CDC23 Q9UJX2 CYB5R2 Homo sapiens Q6BCY4
Y2H Array
25416956
Intra CDC23 Q9UJX2 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra CDC23 Q9UJX2 ATRIP Homo sapiens Q8WXE1
Validated Y2H
25416956
Intra CDC23 Q9UJX2 ATRIP Homo sapiens Q8WXE1
Y2H Array
25416956
Intra CDC23 Q9UJX2 EIF5A2 Homo sapiens Q9GZV4
Validated Y2H
25416956
Intra CDC23 Q9UJX2 EIF5A2 Homo sapiens Q9GZV4
Y2H Array
25416956
Intra CDC23 Q9UJX2 OPTN Homo sapiens Q96CV9
Validated Y2H
25416956
Intra CDC23 Q9UJX2 OPTN Homo sapiens Q96CV9
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra CDC23 Q9UJX2 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra CDC23 Q9UJX2 RSL24D1 Homo sapiens Q9UHA3
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 RSL24D1 Homo sapiens Q9UHA3
Y2H Array
25416956
Intra CDC23 Q9UJX2 PFKFB4 Homo sapiens Q16877
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 PFKFB4 Homo sapiens Q16877
Y2H Array
32296183
Intra CDC23 Q9UJX2 INO80E Homo sapiens Q8NBZ0
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 INO80E Homo sapiens Q8NBZ0
Y2H Array
32296183
Intra CDC23 Q9UJX2 IHO1 Homo sapiens Q8IYA8
Y2H Array
25416956
Intra CDC23 Q9UJX2 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Intra CDC23 Q9UJX2 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Intra CDC23 Q9UJX2 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Intra CDC23 Q9UJX2 COIL Homo sapiens P38432
Y2H Array
25416956
Intra CDC23 Q9UJX2 COIL Homo sapiens P38432
Y2H Prey Pooling
25416956
Intra CDC23 Q9UJX2 COIL Homo sapiens P38432
Validated Y2H
25416956
Intra CDC23 Q9UJX2 KLF11 Homo sapiens O14901
Y2H Array
32814053
Intra CDC23 Q9UJX2 KLF11 Homo sapiens O14901
Y2H Pooling
32814053
Intra CDC23 Q9UJX2 KLF11 Homo sapiens O14901
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurotic Excoriation

Factitious Skin Disease

Dermatitis Artefacta

Dermatitis Factitia

Dermatitis Ficta

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDC23 RGD RGD:1304819
Mus musculus CDC23 MGD MGI:1098815
Felis catus CDC23 VGNC VGNC:82463
Bos taurus CDC23 VGNC VGNC:50038
Macaca mulatta CDC23 VGNC VGNC:70793
Canis familiaris CDC23 VGNC VGNC:51703