2. Gene
  3. Rtkn - rhotekin Gene

Rtkn - rhotekin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 20166 | Gene type: protein coding

About Rtkn

Summary

Enables GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol. Predicted to be active in actomyosin contractile ring. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Apr 2022]

Rtkn Products(10)

mRNA Protein Name
NM_001136227.2 NP_001129699.1 rhotekin isoform a
NM_001355524.2 NP_001342453.2 rhotekin isoform c
NM_001355525.2 NP_001342454.2 rhotekin isoform d
NM_001410312.1 NP_001397241.1 rhotekin isoform e
NM_001410313.1 NP_001397242.1 rhotekin isoform e
NM_001410314.1 NP_001397243.1 rhotekin isoform f
NM_001410315.1 NP_001397244.1 rhotekin isoform g
NM_001410316.1 NP_001397245.1 rhotekin isoform h
NM_009106.3 NP_033132.2 rhotekin isoform b
NM_133641.3 NP_598396.2 rhotekin isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables GTPase inhibitor activity IDA
IDA: Inferred from direct assay
8662891 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18448676 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
8662891 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhotekin

Rtkn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Rtkn Q8C6B2 RHOA Homo sapiens P61586
Pull Down
20300064
Cross
Rtkn Q8C6B2 RHOA Homo sapiens P61586
Pull Down
22404908
Cross
Rtkn Q8C6B2 RHOA Homo sapiens P61586
Pull Down
20348415
Intra
Rtkn Q8C6B2 Rhoa Mus musculus Q9QUI0
Pull Down
20348415
Intra
Rtkn Q8C6B2 Rhoa Mus musculus Q9QUI0
Pull Down
18448676
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12320 RTKN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12321 RTKN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rtkn NCBI NCBI:6242