2. Gene
  3. RTKN - rhotekin Gene

RTKN - rhotekin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 6242 | Gene type: protein coding

About RTKN

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,425,835-74,441,937 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 2 paralogues. Broad expression in kidney (RPKM 18.1), brain (RPKM 12.5) and 23 other tissues.

Summary

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RTKN Products(4)

mRNA Protein Name
NM_001015055.2 NP_001015055.1 rhotekin isoform a
NM_001015056.1 NP_001015056.1 rhotekin isoform c
NM_001410843.1 NP_001397772.1 rhotekin isoform d
NM_033046.2 NP_149035.1 rhotekin isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables GTPase inhibitor activity IDA
IDA: Inferred from direct assay
10940294 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10940294 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
10940294 GOA
Biological Process GO Annotation Evidence Reference Source
involved in Rho protein signal transduction IDA
IDA: Inferred from direct assay
15480428 GOA
involved in regulation of apoptotic process IDA
IDA: Inferred from direct assay
15480428 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
10940294 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTKN Protein Structure

Anillin

Anillin: Cell division protein anillin (116 - 270)

PH

PH: PH domain (313 - 412)

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  • 500
  • 563 a.a.
Protein Preferred Names Protein Names

rhotekin

RTKN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RTKN Q9BST9 SORBS3 Homo sapiens O60504-2
Anti Bait CoIP
19294487
Intra
RTKN Q9BST9 SORBS3 Homo sapiens O60504-2
Pull Down
19294487
Intra
RTKN Q9BST9 RHOA Homo sapiens P61586
Pull Down
22621765
Intra
RTKN Q9BST9 RHOA Homo sapiens P61586
Pull Down
18256687
Intra
RTKN Q9BST9 RHOA Homo sapiens P61586
Pull Down
25150978
Intra
RTKN Q9BST9 RHOA Homo sapiens P61586
Pull Down
22705156
Cross
RTKN Q9BST9 Rhoa Mus musculus Q9QUI0
Pull Down
24525234
Cross
RTKN Q9BST9 Rhoa Mus musculus Q9QUI0
Pull Down
18854161
Intra
RTKN Q9BST9 SORBS3 Homo sapiens O60504
Anti Tag CoIP
19294487
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12320 RTKN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12321 RTKN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RTKN VGNC VGNC:76943
Mus musculus RTKN MGD MGI:107371
Rattus norvegicus RTKN RGD RGD:727874
Canis familiaris RTKN VGNC VGNC:45789
Bos taurus RTKN VGNC VGNC:34197
Felis catus RTKN VGNC VGNC:64807