ENSA - endosulfine alpha Gene

Homo sapiens

Also known as ARPP-19e

Gene ID: 2029 | Gene type: protein coding

About ENSA

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:150,621,246-150,629,612 (from NCBI)

This gene has 15 transcripts (splice variants), 218 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 40.0), esophagus (RPKM 33.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of Insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates Insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

ENSA Products(8)

mRNA	Protein	Name
NM_004436.4	NP_004427.1	alpha-endosulfine isoform 3
NM_207042.2	NP_996925.1	alpha-endosulfine isoform 1
NM_207043.2	NP_996926.1	alpha-endosulfine isoform 2
NM_207044.2	NP_996927.1	alpha-endosulfine isoform 4
NM_207045.2	NP_996928.1	alpha-endosulfine isoform 5
NM_207046.2	NP_996929.1	alpha-endosulfine isoform 6
NM_207047.2	NP_996930.1	alpha-endosulfine isoform 7
NM_207168.2	NP_997051.1	alpha-endosulfine isoform 8

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium channel inhibitor activity	IDA IDA: Inferred from direct assay	9653196	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	9653196	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within regulation of insulin secretion	IDA IDA: Inferred from direct assay	9653196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENSA Protein Structure

Endosulfine

0
100
121 a.a.

Protein Preferred Names

Protein Names

alpha-endosulfine

Recombinant ENSA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74175	ENSA Protein, Human (His)	O43768-1 (M1-E121)	≥95%
HY-P77544	ENSA Protein, Human (Biotinylated, His)	O43768-1 (M1-E121)	≥95%

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 11

Diabetes Mellitus, Insulin-Dependent, 11	Iddm11
Insulin-Dependent Diabetes Mellitus 11	T1D11
Insulin-Dependent Diabetes Mellitus-11

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04394	ENSA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ENSA	RGD	RGD:62007
Felis catus	ENSA	VGNC	VGNC:61877
Mus musculus	ENSA	MGD	MGI:1891189
Canis familiaris	ENSA	VGNC	VGNC:40379
Macaca mulatta	ENSA	VGNC	VGNC:99904
Bos taurus	ENSA	VGNC	VGNC:50171
Others	ENSA	NCBI

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