SLC44A5 - solute carrier family 44 member 5 Gene

Homo sapiens

Also known as CTL5

Gene ID: 204962 | Gene type: protein coding

About SLC44A5

This gene has 3 transcripts (splice variants), 248 orthologues and 4 paralogues. Broad expression in skin (RPKM 2.6), testis (RPKM 1.3) and 21 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC44A5 Products(6)

mRNA	Protein	Name
NM_001130058.2	NP_001123530.1	choline transporter-like protein 5 isoform B
NM_001320283.3	NP_001307212.1	choline transporter-like protein 5 isoform C
NM_001320285.2	NP_001307214.1	choline transporter-like protein 5 isoform D precursor
NM_001320287.2	NP_001307216.1	choline transporter-like protein 5 isoform D precursor
NM_001394064.1	NP_001380993.1	choline transporter-like protein 5 isoform E
NM_152697.6	NP_689910.2	choline transporter-like protein 5 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	23651124	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in choline transport	IDA IDA: Inferred from direct assay	23651124	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	23651124	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC44A5 Protein Structure

Choline_transpo

0
200
400
600
719 a.a.

Protein Preferred Names

Protein Names

choline transporter-like protein 5

SLC44A5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC44A5	Q8NCS7	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	SLC44A5	Q8NCS7	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	SLC44A5	Q8NCS7	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	SLC44A5	Q8NCS7	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	SLC44A5	Q8NCS7	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	SLC44A5	Q8NCS7	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
Intra	SLC44A5	Q8NCS7	CBX5	Homo sapiens	P45973	Validated Y2H	32814053
Intra	SLC44A5	Q8NCS7	CBX5	Homo sapiens	P45973	Y2H Array	32814053
Intra	SLC44A5	Q8NCS7	CBX5	Homo sapiens	P45973	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 25

RP25	Retinitis Pigmentosa-25
Retinitis Pigmentosa, Type 25

Choline Deficiency Disease

Choline Deficiency

Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect	Dicarboxylicaminoaciduria
DCBXA	Renal Aminoacidurias

Iminoglycinuria

Iminoglycinuria, Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13255	SLC44A5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC44A5	VGNC	VGNC:77785
Rattus norvegicus	SLC44A5	RGD	RGD:1564620
Bos taurus	SLC44A5	VGNC	VGNC:34879
Mus musculus	SLC44A5	MGD	MGI:3035141
Canis familiaris	SLC44A5	VGNC	VGNC:46421
Felis catus	SLC44A5	VGNC	VGNC:65375

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