CBX5 - chromobox 5 Gene

Homo sapiens

Also known as HP1; HP1A; HEL25

Gene ID: 23468 | Gene type: protein coding

About CBX5

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,230,942-54,280,122 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 15.3), thyroid (RPKM 14.2) and 25 other tissues.

Summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

CBX5 Products(3)

mRNA	Protein	Name
NM_001127321.1	NP_001120793.1	chromobox protein homolog 5
NM_001127322.1	NP_001120794.1	chromobox protein homolog 5
NM_012117.3	NP_036249.1	chromobox protein homolog 5

CBX5 Protein Structure

Chromo

Chromo_shadow

0
100
191 a.a.

Protein Preferred Names

Protein Names

chromobox protein homolog 5

HP1 alpha homolog

CBX5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	Anti Tag CoIP	20562864
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	Y2H	20562864
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	Anti Tag CoIP	19498464
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	TAP	24981860
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	TAP	27705803
Intra	CBX5	P45973	LBR	Homo sapiens	Q14739	Pull Down	8663349
Intra	CBX5	P45973	MFSD10	Homo sapiens	Q14728	Y2H Array	32814053
Intra	CBX5	P45973	MFSD10	Homo sapiens	Q14728	Y2H Pooling	32814053
Intra	CBX5	P45973	MFSD10	Homo sapiens	Q14728	Validated Y2H	32814053
Intra	CBX5	P45973	ZNF280D	Homo sapiens	Q6N043-2	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	ZNF280D	Homo sapiens	Q6N043-2	Y2H Array	32296183
Intra	CBX5	P45973	ZNF280D	Homo sapiens	Q6N043-2	Validated Y2H	32296183
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	Anti Tag CoIP	19498464
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	Anti Tag CoIP	20562864
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	TAP	24981860
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	TAP	27705803
Intra	CBX5	P45973	ADNP	Homo sapiens	Q9H2P0	TAP	27705803
Intra	CBX5	P45973	ADNP	Homo sapiens	Q9H2P0	Anti Tag CoIP	20562864
Intra	CBX5	P45973	ATG13	Homo sapiens	O75143-2	Validated Y2H	32814053
Intra	CBX5	P45973	ATG13	Homo sapiens	O75143-2	Y2H Array	32814053
Intra	CBX5	P45973	ATG13	Homo sapiens	O75143-2	Y2H Pooling	32814053
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95-3	Validated Y2H	32814053
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95-3	Y2H Array	32814053
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95-3	Y2H Pooling	32814053
Intra	CBX5	P45973	LAP3	Homo sapiens	P28838	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Y2H Pooling	32814053
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	TAP	24981860
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	TAP	27705803
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	20562864
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Validated Y2H	32814053
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Y2H Array	32814053
Intra	CBX5	P45973	PIGV	Homo sapiens	Q9NUD9	Validated Y2H	32814053
Intra	CBX5	P45973	PIGV	Homo sapiens	Q9NUD9	Y2H Array	32814053
Intra	CBX5	P45973	PIGV	Homo sapiens	Q9NUD9	Y2H Pooling	32814053
Intra	CBX5	P45973	ARFGAP3	Homo sapiens	Q9NP61	Validated Y2H	32814053
Intra	CBX5	P45973	ARFGAP3	Homo sapiens	Q9NP61	Y2H Array	32814053
Intra	CBX5	P45973	ARFGAP3	Homo sapiens	Q9NP61	Y2H Pooling	32814053
Intra	CBX5	P45973	H4C16	Homo sapiens	P62805	TAP	24981860
Intra	CBX5	P45973	H4C16	Homo sapiens	P62805	Crosslink	30021884
Intra	CBX5	P45973	H4C16	Homo sapiens	P62805	TAP	21888893
Intra	CBX5	P45973	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	20562864
Intra	CBX5	P45973	INCENP	Homo sapiens	Q9NQS7	Pull Down	21346195
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95	Y2H	21516116
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95	Lumier	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Validated Y2H	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Array	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	20562864
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Pooling	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Array	32296183
Intra	CBX5	P45973	H3-4	Homo sapiens	Q16695	TAP	21888893
Intra	CBX5	P45973	ATRX	Homo sapiens	P46100	Anti Bait CoIP	10699177
Intra	CBX5	P45973	MYC	Homo sapiens	P01106	Y2H Pooling	32814053
Intra	CBX5	P45973	MYC	Homo sapiens	P01106	Validated Y2H	32814053
Intra	CBX5	P45973	MYC	Homo sapiens	P01106	Y2H Array	32814053
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Anti Tag CoIP	23542155
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	TAP	27705803
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32296183
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Anti Tag CoIP	20562864
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
Intra	CBX5	P45973	SP100	Homo sapiens	P23497-2	BFG-2H	27107012
Intra	CBX5	P45973	SP100	Homo sapiens	P23497-2	Validated Y2H	27107012
Intra	CBX5	P45973	DDX19B	Homo sapiens	Q9UMR2	Y2H Array	32814053
Intra	CBX5	P45973	DDX19B	Homo sapiens	Q9UMR2	Validated Y2H	32814053
Intra	CBX5	P45973	DDX19B	Homo sapiens	Q9UMR2	Y2H Pooling	32814053
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Anti Tag CoIP	20562864
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	TAP	27705803
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Array	31515488
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Pooling	16189514
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Validated Y2H	32296183
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Array	32296183
Intra	CBX5	P45973	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Array	32814053
Intra	CBX5	P45973	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Pooling	32814053
Intra	CBX5	P45973	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32814053
Intra	CBX5	P45973	SENP7	Homo sapiens	Q9BQF6	Anti Tag CoIP	20562864
Intra	CBX5	P45973	SENP7	Homo sapiens	Q9BQF6	TAP	27705803
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	TAP	24981860
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	TAP	27705803
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	TAP	21888893
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	Anti Tag CoIP	20562864
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	Anti Tag CoIP	19498464
Intra	CBX5	P45973	PPARA	Homo sapiens	Q07869	Y2H Array	32814053
Intra	CBX5	P45973	PPARA	Homo sapiens	Q07869	Validated Y2H	32814053
Intra	CBX5	P45973	PPARA	Homo sapiens	Q07869	Y2H Pooling	32814053
Intra	CBX5	P45973	H3C1	Homo sapiens	P68431	Pull Down	16415788
Intra	CBX5	P45973	H3C1	Homo sapiens	P68431	Protein Array	20871592
Intra	CBX5	P45973	MBD1	Homo sapiens	Q9UIS9	Anti Bait CoIP	12711603
Intra	CBX5	P45973	MBD1	Homo sapiens	Q9UIS9	Pull Down	12711603
Intra	CBX5	P45973	MBD1	Homo sapiens	Q9UIS9	Confocal	12711603
Intra	CBX5	P45973	ZNF280C	Homo sapiens	Q8ND82	Validated Y2H	32296183
Cross	CBX5	P45973	legAS4	Legionella pneumophila subsp. pneumophila	Q5ZUS4	Y2H	23797873
Cross	CBX5	P45973	legAS4	Legionella pneumophila subsp. pneumophila	Q5ZUS4	Anti Bait CoIP	23797873
Intra	CBX5	P45973	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	CBX5	P45973	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	CBX5	P45973	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053
Intra	CBX5	P45973	SGO1	Homo sapiens	Q5FBB7	TAP	24981860
Intra	CBX5	P45973	SGO1	Homo sapiens	Q5FBB7	Anti Tag CoIP	20562864

Cross: Cross-species interaction Intra: Intraspecies interaction

CBX5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81280	HP1 alpha Antibody (YA981)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P81280A	HP1 alpha Antibody (YA982)	WB, IHC-P	Human, Rat, Mouse
HY-P81280B	HP1 alpha Antibody (YA983)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Reynolds Syndrome

Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia	Primary Biliary Cirrhosis And Systemic Scleroderma
REYNS	Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Alpha Thalassemia-X-Linked Intellectual Disability Syndrome

Atr-X Syndrome	Atr, Nondeletion Type
Alpha-Thalassemia X-Linked Intellectual Disability Syndrome	Atrx Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type	Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked
X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome	Xlmr Hypotonic Face Syndrome
Alpha Thalassemia X-Linked Intellectual Disability Syndrome	Alpha Thalassemia X-Linked Mental Retardation Syndrome
Alpha Thalassemia/Mental Retardation, X-Linked	Alpha-Thalassemia X-Linked Mental Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type	X-Linked Alpha-Thalassemia/Mental Retardation Syndrome
Xlmr-Hypotonic Face Syndrome	Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked

White-Sutton Syndrome

WHSUS	Mrd37
Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome	Mental Retardation, Autosomal Dominant 37
Autosomal Dominant Mental Retardation 37	Pogz-Related Intellectual Disability Syndrome

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142952	UNC6864 (Kei)	Inhibitor	/	Unkown
HY-142953	UNC6349 (Ket2)	Inhibitor	/	Unkown
HY-142954	UNC6212 (Kme2)	Inhibitor	/	Unkown
HY-RS02012	CBX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CBX5	VGNC	VGNC:70559
Rattus norvegicus	CBX5	RGD	RGD:1306619
Bos taurus	CBX5	VGNC	VGNC:26818
Canis familiaris	CBX5	VGNC	VGNC:38767
Mus musculus	CBX5	MGD	MGI:109372

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