Snap25 - synaptosomal-associated protein 25 Gene

Mus musculus

Also known as sp; Bdr; SUP; GENA70; SNAP-25

Gene ID: 20614 | Gene type: protein coding

About Snap25

Summary

Enables syntaxin-1 binding activity. Involved in exocytosis; neurotransmitter receptor internalization; and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; neurotransmitter secretion; and regulation of synaptic plasticity. Located in several cellular components, including glutamatergic synapse; synaptic vesicle; and trans-Golgi network. Is extrinsic component of cytoplasmic side of plasma membrane. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Apr 2022]

Snap25 Products(24)

mRNA	Protein	Name
NM_001291056.2	NP_001277985.1	synaptosomal-associated protein 25 isoform b
NM_001355254.1	NP_001342183.1	synaptosomal-associated protein 25 isoform a
NM_001355255.2	NP_001342184.1	synaptosomal-associated protein 25 isoform c
NM_001412615.1	NP_001399544.1	synaptosomal-associated protein 25 isoform a
NM_001412616.1	NP_001399545.1	synaptosomal-associated protein 25 isoform a
NM_001412617.1	NP_001399546.1	synaptosomal-associated protein 25 isoform b
NM_001412618.1	NP_001399547.1	synaptosomal-associated protein 25 isoform c
NM_001412619.1	NP_001399548.1	synaptosomal-associated protein 25 isoform d
NM_001412620.1	NP_001399549.1	synaptosomal-associated protein 25 isoform d
NM_001412621.1	NP_001399550.1	synaptosomal-associated protein 25 isoform e
NM_001412622.1	NP_001399551.1	synaptosomal-associated protein 25 isoform f
NM_011428.4	NP_035558.1	synaptosomal-associated protein 25 isoform a
NM_001291056.2	NP_001277985.1	synaptosomal-associated protein 25 isoform b
NM_001355254.1	NP_001342183.1	synaptosomal-associated protein 25 isoform a
NM_001355255.2	NP_001342184.1	synaptosomal-associated protein 25 isoform c
NM_001412615.1	NP_001399544.1	synaptosomal-associated protein 25 isoform a
NM_001412616.1	NP_001399545.1	synaptosomal-associated protein 25 isoform a
NM_001412617.1	NP_001399546.1	synaptosomal-associated protein 25 isoform b
NM_001412618.1	NP_001399547.1	synaptosomal-associated protein 25 isoform c
NM_001412619.1	NP_001399548.1	synaptosomal-associated protein 25 isoform d
NM_001412620.1	NP_001399549.1	synaptosomal-associated protein 25 isoform d
NM_001412621.1	NP_001399550.1	synaptosomal-associated protein 25 isoform e
NM_001412622.1	NP_001399551.1	synaptosomal-associated protein 25 isoform f
NM_011428.4	NP_035558.1	synaptosomal-associated protein 25 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	12145198	MGI
enables SNARE binding	IDA IDA: Inferred from direct assay	12145198	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16565726	MGI
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	18703708	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	23064108	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	23064108	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	23395379	MGI
acts upstream of or within neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	11753414	MGI
involved in presynaptic dense core vesicle exocytosis	IDA IDA: Inferred from direct assay	28404788	MGI
involved in presynaptic dense core vesicle exocytosis	IEP IEP: Inferred from expression pattern	28404788	MGI
involved in presynaptic dense core vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	28404788	MGI
acts upstream of or within regulation of establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23395379	MGI
involved in regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	21986494	MGI
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	17728451	MGI
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	17728451	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21576241	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	23821748	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19546860	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17728451	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17728451	MGI
located in membrane	IDA IDA: Inferred from direct assay	19546860	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	14622145	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18827011	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	24680688	MGI
located in ribbon synapse	IDA IDA: Inferred from direct assay	24680688	MGI
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	21576241	MGI
located in synapse	IDA IDA: Inferred from direct assay	10712642	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	24680688	MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA IDA: Inferred from direct assay	21040848	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	18827011	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptosomal-associated protein 25

blind drunk	super protein
synaptosomal-associated 25 kDa protein	synaptosomal-associated protein, 25 kDa

Snap25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Anti Bait CoIP	16672379
Intra	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Fluorescence	18827011
Intra	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Confocal	16672379
Intra	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Y2H	16672379
Intra	Snap25	P60879	Cenpf	Mus musculus	Q155P7	Anti Tag CoIP	16672379
Intra	Snap25	P60879	Stx1a	Mus musculus	O35526	Anti Bait CoIP	20114047
Intra	Snap25	P60879	Stx1a	Mus musculus	O35526	Anti Bait CoIP	24705552
Intra	Snap25	P60879	Vamp2	Mus musculus	P63044	Comigration in SDS	19703397
Intra	Snap25	P60879	Vamp2	Mus musculus	P63044	Anti Bait CoIP	24705552
Intra	Snap25	P60879	Vamp2	Mus musculus	P63044	Anti Bait CoIP	20114047
Intra	Snap25	P60879	Vamp2	Mus musculus	P63044	Comigration in SDS	19805029
Intra	Snap25	P60879	Vamp2	Mus musculus	P63044	Anti Bait CoIP	20798282
Intra	Snap25	P60879	Vamp2	Mus musculus	P63044	Density Sedimentation	16565726
Cross	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Affinity Techniques	19703397
Cross	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Density Sedimentation	16565726
Cross	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Comigration in SDS	19703397
Cross	Snap25	P60879	Stx1a	Rattus norvegicus	P32851	Comigration in SDS	19805029

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13474	SNAP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snap25	NCBI	NCBI:6616

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