2. Gene
  3. Plk4 - polo like kinase 4 Gene

Plk4 - polo like kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sak; Stk18; 1700028H20

Gene ID: 20873 | Gene type: protein coding

About Plk4

Chromosome 3: 40,754,454-40,771,318 forward strand.GRCm39:CM000996.3

This gene has 10 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 12 phenotypes. Broad expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 9.6) and 16 other tissues.

Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Plk4 Products(4)

mRNA Protein Name
NM_173169.3 NP_775261.2 serine/threonine-protein kinase PLK4 isoform 2
NM_001410621.1 NP_001397550.1 serine/threonine-protein kinase PLK4 isoform 3
NM_001410622.1 NP_001397551.1 serine/threonine-protein kinase PLK4 isoform 4
NM_011495.3 NP_035625.2 serine/threonine-protein kinase PLK4 isoform 1

Plk4 Protein Structure

STKc_PLK4

STKc_PLK4: cd14186 (9 - 264)

POLO_box_Plk4_1

POLO_box_Plk4_1: cd13114 (547 - 658)

Plk4_PB2

Plk4_PB2: pfam18409 (659 - 767)

POLO_box_Plk4_3

POLO_box_Plk4_3: cd13116 (838 - 917)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 925 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK4

serine/threonine kinase 18

serine/threonine-protein kinase 18

serine/threonine-protein kinase Sak

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12300B Ocifisertib fumarate Inhibitor 99.44% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18682 Centrinone Inhibitor 98.16% Unkown
HY-18683 Centrinone-B Inhibitor 98.46% Unkown
HY-100789 ON1231320 Inhibitor 99.24% Unkown
HY-12300 Ocifisertib Inhibitor 99.92% Unkown
HY-132135 (1E)-CFI-400437 dihydrochloride Inhibitor 98.08% Unkown
HY-128493 PLK4-IN-4 Inhibitor 99.89% Unkown
HY-134775A PLK4-IN-3 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-149912 CZS-241 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk4 NCBI NCBI:10733