Plk4 - polo like kinase 4 Gene

Mus musculus

Also known as Sak; Stk18; 1700028H20

Gene ID: 20873 | Gene type: protein coding

About Plk4

Chromosome 3: 40,754,454-40,771,318 forward strand.GRCm39:CM000996.3

This gene has 10 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 12 phenotypes. Broad expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 9.6) and 16 other tissues.

Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Plk4 Products(4)

mRNA	Protein	Name
NM_173169.3	NP_775261.2	serine/threonine-protein kinase PLK4 isoform 2
NM_001410621.1	NP_001397550.1	serine/threonine-protein kinase PLK4 isoform 3
NM_001410622.1	NP_001397551.1	serine/threonine-protein kinase PLK4 isoform 4
NM_011495.3	NP_035625.2	serine/threonine-protein kinase PLK4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17174311	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17174311	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17891141	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	24240477	MGI
involved in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	24240477	MGI
involved in trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	17891141	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in XY body	IDA IDA: Inferred from direct assay	22854038	MGI
located in deuterosome	IDA IDA: Inferred from direct assay	24240477	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	17891141	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk4 Protein Structure

STKc_PLK4

POLO_box_Plk4_1

Plk4_PB2

POLO_box_Plk4_3

0
200
400
600
800
925 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PLK4

serine/threonine kinase 18	serine/threonine-protein kinase 18
serine/threonine-protein kinase Sak

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12300B	Ocifisertib fumarate	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18682	Centrinone	Inhibitor	98.16%	Unkown
HY-18683	Centrinone-B	Inhibitor	98.46%	Unkown
HY-100789	ON1231320	Inhibitor	99.24%	Unkown
HY-12300	Ocifisertib	Inhibitor	99.78%	Unkown
HY-132135	(1E)-CFI-400437 dihydrochloride	Inhibitor	98.08%	Unkown
HY-128493	PLK4-IN-4	Inhibitor	99.89%	Unkown
HY-134775A	PLK4-IN-3	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-149912	CZS-241	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plk4	NCBI	NCBI:10733

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