PLK4 - polo like kinase 4 Gene

Homo sapiens

Also known as SAK; STK18; MCCRP2

Gene ID: 10733 | Gene type: protein coding

About PLK4

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:127,880,893-127,899,224 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 5 phenotypes. Biased expression in testis (RPKM 12.2), bone marrow (RPKM 8.2) and 12 other tissues.

Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

PLK4 Products(6)

mRNA	Protein	Name
NM_001190799.2	NP_001177728.1	serine/threonine-protein kinase PLK4 isoform 2
NM_014264.5	NP_055079.3	serine/threonine-protein kinase PLK4 isoform 1
XM_017007662.2	XP_016863151.1	serine/threonine-protein kinase PLK4 isoform X1
XM_017007663.3	XP_016863152.1	serine/threonine-protein kinase PLK4 isoform X2
XM_005262701.4	XP_005262758.1	serine/threonine-protein kinase PLK4 isoform X3
NM_001190801.2	NP_001177730.1	serine/threonine-protein kinase PLK4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21725316	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centriole replication	IDA IDA: Inferred from direct assay	21059844	GOA
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	21725316	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	30804208	GOA
acts upstream of or within positive regulation of centriole replication	IDA IDA: Inferred from direct assay	22349705	GOA
involved in positive regulation of centriole replication	IDA IDA: Inferred from direct assay	27796307	GOA
involved in positive regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	16244668	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	27796307	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriole	IDA IDA: Inferred from direct assay	16244668	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in procentriole	IDA IDA: Inferred from direct assay	24997597	GOA
part of procentriole replication complex	IPI IPI: Inferred from physical interaction	24997597	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLK4 Protein Structure

Pkinase

POLO_box

0
200
400
600
800
970 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PLK4

Snk akin kinase	serine/threonine-protein kinase 18
serine/threonine-protein kinase Sak

PLK4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLK4	O00444	OSBPL3	Homo sapiens	Q9H4L5	Validated Y2H	32296183
Intra	PLK4	O00444	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	PLK4	O00444	GAS8	Homo sapiens	O95995	Validated Y2H	32296183
Intra	PLK4	O00444	ECT2	Homo sapiens	Q9H8V3	Anti Bait CoIP	20348415
Intra	PLK4	O00444	ECT2	Homo sapiens	Q9H8V3	Anti Tag CoIP	20348415
Intra	PLK4	O00444	ECT2	Homo sapiens	Q9H8V3	Protein Kinase Assay	20348415
Intra	PLK4	O00444	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	PLK4	O00444	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	PLK4	O00444	DNAJB13	Homo sapiens	P59910	Validated Y2H	32296183
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	FPS	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	GMS	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Anti Tag CoIP	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Anti Tag CoIP	21059844
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Pull Down	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Pull Down	20852615
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Pull Down	21059844
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	X-Ray Diffraction	24997597
Intra	PLK4	O00444	CEP192	Homo sapiens	Q8TEP8-3	Anti Tag CoIP	24997597
Intra	PLK4	O00444	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	PLK4	O00444	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	PLK4	O00444	CEP192	Homo sapiens	Q8TEP8	Pull Down	26188084
Intra	PLK4	O00444	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Bait CoIP	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Tag CoIP	26496610
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Pull Down	26188084
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Bait CoIP	21059844
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Tag CoIP	26188084
Intra	PLK4	O00444	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PLK4	O00444	P4HB	Homo sapiens	P07237	Validated Y2H	32814053
Intra	PLK4	O00444	P4HB	Homo sapiens	P07237	Y2H Pooling	32814053
Intra	PLK4	O00444	P4HB	Homo sapiens	P07237	Y2H Array	32814053
Intra	PLK4	O00444	SPAG5	Homo sapiens	Q96R06	Y2H Array	32296183
Intra	PLK4	O00444	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	SPAG5	Homo sapiens	Q96R06	Validated Y2H	32296183
Intra	PLK4	O00444	SFN	Homo sapiens	P31947	Pull Down	16189514
Intra	PLK4	O00444	ARR3	Homo sapiens	P36575	Validated Y2H	25416956
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Y2H Prey Pooling	25416956
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Validated Y2H	25416956
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Y2H Array	25416956
Intra	PLK4	O00444	PLK4	Homo sapiens	O00444	Y2H Pooling	16189514
Intra	PLK4	O00444	PLK4	Homo sapiens	O00444	Anti Tag CoIP	24997597
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	ITC	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	Anti Tag CoIP	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	Pull Down	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	IF	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	Protein Kinase Assay	26188084
Intra	PLK4	O00444	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	PLK4	O00444	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	PLK4	O00444	ZBTB39	Homo sapiens	O15060	Y2H Array	32296183
Intra	PLK4	O00444	ZBTB39	Homo sapiens	O15060	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	ZBTB39	Homo sapiens	O15060	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly And Chorioretinopathy, Autosomal Recessive, 2

MCCRP2

Microcephaly And Chorioretinopathy, Autosomal Recessive, Type 2

Microcephaly And Chorioretinopathy 2

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Isolated Growth Hormone Deficiency Type Ia
Primordial Dwarfism	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome

Autosomal Recessive Chorioretinopathy-Microcephaly-Intellectual Disability Syndrome

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Spermatogenic Failure 10

SPGF10	Spermatogenic Failure With Defective Sperm Annulus
Spermatogenic Failure, Type 10

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12300B	Ocifisertib fumarate	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18682	Centrinone	Inhibitor	98.16%	Unkown
HY-18683	Centrinone-B	Inhibitor	98.46%	Unkown
HY-100789	ON1231320	Inhibitor	99.24%	Unkown
HY-12300	Ocifisertib	Inhibitor	99.78%	Unkown
HY-132135	(1E)-CFI-400437 dihydrochloride	Inhibitor	98.08%	Unkown
HY-128493	PLK4-IN-4	Inhibitor	99.89%	Unkown
HY-134775A	PLK4-IN-3	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-149912	CZS-241	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLK4	VGNC	VGNC:64246
Canis familiaris	PLK4	VGNC	VGNC:44698
Bos taurus	PLK4	VGNC	VGNC:33036
Macaca mulatta	PLK4	VGNC	VGNC:76019
Mus musculus	PLK4	MGD	MGI:101783
Rattus norvegicus	PLK4	RGD	RGD:1305390
Others	PLK4	NCBI

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