2. Gene
  3. ETF1 - eukaryotic translation termination factor 1 Gene

ETF1 - eukaryotic translation termination factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1

Gene ID: 2107 | Gene type: protein coding

About ETF1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,506,095-138,543,236 (from NCBI)

This gene has 9 transcripts (splice variants) and 246 orthologues. Ubiquitous expression in bone marrow (RPKM 46.6), esophagus (RPKM 37.2) and 25 other tissues.

Summary

This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

ETF1 Products(6)

mRNA Protein Name
NM_001256302.2 NP_001243231.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001282185.2 NP_001269114.1 eukaryotic peptide chain release factor subunit 1 isoform 3
NM_001291974.2 NP_001278903.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001291975.2 NP_001278904.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_001364160.2 NP_001351089.1 eukaryotic peptide chain release factor subunit 1 isoform 2
NM_004730.4 NP_004721.1 eukaryotic peptide chain release factor subunit 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aminoacyl-tRNA hydrolase activity IDA
IDA: Inferred from direct assay
16777602 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9620853 GOA
enables sequence-specific mRNA binding IMP
IMP: Inferred from mutant phenotype
12909007 GOA
enables translation release factor activity IDA
IDA: Inferred from direct assay
7990965 GOA
enables translation termination factor activity IDA
IDA: Inferred from direct assay
10445876 GOA
enables translation termination factor activity IMP
IMP: Inferred from mutant phenotype
24486019 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within protein methylation IDA
IDA: Inferred from direct assay
18539146 GOA
involved in regulation of translational termination IMP
IMP: Inferred from mutant phenotype
30682371 GOA
acts upstream of or within translational termination IDA
IDA: Inferred from direct assay
7990965 GOA
involved in translational termination IDA
IDA: Inferred from direct assay
10445876 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
10445876 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
part of translation release factor complex IDA
IDA: Inferred from direct assay
26245381 GOA
part of translation release factor complex IPI
IPI: Inferred from physical interaction
19417105 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETF1 Protein Structure

eRF1_1

eRF1_1: eRF1 domain 1 (9 - 139)

eRF1_2

eRF1_2: eRF1 domain 2 (145 - 277)

eRF1_3

eRF1_3: eRF1 domain 3 (280 - 417)

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  • 437 a.a.
Protein Preferred Names Protein Names

eukaryotic peptide chain release factor subunit 1

polypeptide chain release factor 1

ETF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ETF1 P62495 GSPT2 Homo sapiens Q8IYD1
Anti Tag CoIP
18447585
Intra
ETF1 P62495 KEAP1 Homo sapiens Q14145
Y2H Pooling
16189514
Intra
ETF1 P62495 KEAP1 Homo sapiens Q14145
Y2H Prey Pooling
32296183
Intra
ETF1 P62495 KEAP1 Homo sapiens Q14145
Validated Y2H
32296183
Intra
ETF1 P62495 KEAP1 Homo sapiens Q14145
Y2H Array
32296183
Intra
ETF1 P62495 GSPT1 Homo sapiens P15170
3D-EM
24335085
Intra
ETF1 P62495 GSPT1 Homo sapiens P15170
3D-EM
23091004
Intra
ETF1 P62495 GSPT1 Homo sapiens P15170
Anti Tag CoIP
18256688
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis

Hme

Human Ehrlichial Infection, Human Monocytic Type
Ulna And Fibula, Absence Of, With Severe Limb Deficiency

Schinzel Phocomelia Syndrome

Aarrs

Limb/Pelvis-Hypoplasia/Aplasia Syndrome

LPHAS

Schinzel Type Phocomelia

Absence Of Ulna And Fibula With Severe Limb Deficiency

Al-Awadi/Raas-Rothschild Syndrome

Al Awadi-Raas-Rothschild Syndrome

Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome

Aplasia/Hypoplasia Of Limbs And Pelvis

Congenital Absence Of Ulna And Fibula

Severe Limb Deficit

Phocomelia, Schinzel Type

Al-Awadi-Raas-Rothschild Syndrome

Ulna And Fibula Absence Of With Severe Limb Deficiency

Limb Pelvis Hypoplasia Aplasia Syndrome

Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome

Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Bone Chondrosarcoma
Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis

Hge

Human Ehrlichial Infection, Human Granulocytic Type

Human Anaplasmosis Due To Anaplasma Phagocytophilum
Ehrlichiosis

Human Ehrlichiosis

He

Hey
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04554 ETF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ETF1 VGNC VGNC:84370
Felis catus ETF1 VGNC VGNC:97422
Bos taurus ETF1 VGNC VGNC:28617
Mus musculus ETF1 MGD MGI:2385071
Rattus norvegicus ETF1 RGD RGD:1305712
Others ETF1 NCBI