2,5-Dimethylcelecoxib

Cat. No.: HY-W010995 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin.

For research use only. We do not sell to patients.

2,5-Dimethylcelecoxib Chemical Structure

CAS No. : 457639-26-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2,5-Dimethylcelecoxib:

2,5-Dimethylcelecoxib-d₄ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	36 μM Compound: DMC	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTS assay	[PMID: 22780961]

Molecular Weight

395.40

Formula

C₁₈H₁₆F₃N₃O₂S

CAS No.

457639-26-8

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC(C)=CC=C3C)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (252.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5291 mL	12.6454 mL	25.2908 mL
5 mM	0.5058 mL	2.5291 mL	5.0582 mL
10 mM	0.2529 mL	1.2645 mL	2.5291 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (276 KB) SDS (420 KB)

COA (256 KB) RP-HPLC (132 KB)

Handling Instructions (2659 KB)

References

[1]. Egashira I, et al. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway. Cancer Sci. 2017 Jan;108(1):108-115. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5291 mL	12.6454 mL	25.2908 mL	63.2271 mL
	5 mM	0.5058 mL	2.5291 mL	5.0582 mL	12.6454 mL
	10 mM	0.2529 mL	1.2645 mL	2.5291 mL	6.3227 mL
	15 mM	0.1686 mL	0.8430 mL	1.6861 mL	4.2151 mL
	20 mM	0.1265 mL	0.6323 mL	1.2645 mL	3.1614 mL
	25 mM	0.1012 mL	0.5058 mL	1.0116 mL	2.5291 mL
	30 mM	0.0843 mL	0.4215 mL	0.8430 mL	2.1076 mL
	40 mM	0.0632 mL	0.3161 mL	0.6323 mL	1.5807 mL
	50 mM	0.0506 mL	0.2529 mL	0.5058 mL	1.2645 mL
	60 mM	0.0422 mL	0.2108 mL	0.4215 mL	1.0538 mL
	80 mM	0.0316 mL	0.1581 mL	0.3161 mL	0.7903 mL
	100 mM	0.0253 mL	0.1265 mL	0.2529 mL	0.6323 mL