FABP5 - fatty acid binding protein 5 Gene

Homo sapiens

Also known as EFABP; KFABP; E-FABP; PAFABP; PA-FABP

Gene ID: 2171 | Gene type: protein coding

About FABP5

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,280,536-81,284,775 (from NCBI)

This gene has 4 transcripts (splice variants), 447 orthologues and 15 paralogues. Biased expression in esophagus (RPKM 725.7), fat (RPKM 171.7) and 11 other tissues.

Summary

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

FABP5 Products(1)

mRNA	Protein	Name
NM_001444.3	NP_001435.1	fatty acid-binding protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acid binding	IDA IDA: Inferred from direct assay	8092987	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	24531463	GOA
enables long-chain fatty acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21395585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12839573	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid transport across blood-brain barrier	IMP IMP: Inferred from mutant phenotype	21395585	GOA
involved in long-chain fatty acid transport	IMP IMP: Inferred from mutant phenotype	21395585	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8092987	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24692551	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FABP5 Protein Structure

Lipocalin

0
100
135 a.a.

Protein Preferred Names

Protein Names

fatty acid-binding protein 5

epidermal-type fatty acid-binding protein

Recombinant FABP5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72660	FABP5 Protein, Human (His)	Q01469 (A2-E135)	≥95%
HY-P75214	FABP5 Protein, Human	Q01469 (M1-E135)	≥95%

Related Diseases

Diseases

Alias

Psoriasis

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101903	BMS-309403	Inhibitor	99.93%	Unkown
HY-101903A	BMS-309403 sodium	Inhibitor	99.94%	Unkown
HY-145990	FABPs ligand 6	Inhibitor	98.57%	Unkown
HY-159115	ART26.12	Inhibitor	99.57%	Unkown
HY-161702	RO6806051	Inhibitor	99.84%	Unkown
HY-N8144	Niga-ichigoside F1		≥99.0%	Unkown
HY-RS04661	FABP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160456	FABP4/5-IN-4	Inhibitor	/	Unkown
HY-160457	FABP4/5-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FABP5	RGD	RGD:70997
Felis catus	FABP5	VGNC	VGNC:81655
Mus musculus	FABP5	MGD	MGI:101790
Others	FABP5	NCBI

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