Tff2 - trefoil factor 2 (spasmolytic protein 1) Gene

Mus musculus

Also known as SP; mSP

Gene ID: 21785 | Gene type: protein coding

About Tff2

Summary

Enables CXCR4 Chemokine Receptor binding activity. Acts upstream of or within several processes, including negative regulation of gastric acid secretion; negative regulation of macrophage activation; and positive regulation of ERK1 and ERK2 cascade. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; liver; skeleton; and thymus. Orthologous to human TFF2 (trefoil factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tff2 Products(1)

mRNA	Protein	Name
NM_009363.3	NP_033389.2	trefoil factor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CXCR4 chemokine receptor binding	IDA IDA: Inferred from direct assay	19064997	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium-mediated signaling	IDA IDA: Inferred from direct assay	19064997	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11805131	MGI
acts upstream of or within chemokine-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	19064997	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	11805131	MGI
acts upstream of gastric acid secretion	IMP IMP: Inferred from mutant phenotype	11805131	MGI
acts upstream of macrophage activation	IMP IMP: Inferred from mutant phenotype	17101660	MGI
acts upstream of or within negative regulation of gastric acid secretion	IMP IMP: Inferred from mutant phenotype	11805131	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	17101660	MGI
acts upstream of or within negative regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	17101660	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	19064997	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	19064997	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11805131	MGI
acts upstream of or within regulation of cell migration	IGI IGI: Inferred from genetic interaction	19064997	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19064997	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

trefoil factor 2

spasmolytic polypeptide

Recombinant Tff2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71355	TFF2 Protein, Mouse (HEK293, His)	Q03404 (E24-Y129)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14423	TFF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tff2	NCBI	NCBI:7032

Name
Email *

	Sorry, but the email address you supplied was invalid.