FARSA - phenylalanyl-tRNA synthetase subunit alpha Gene

Homo sapiens

Also known as FRSA; CML33; FARSL; PheHA; FARSLA; RILDBC2

Gene ID: 2193 | Gene type: protein coding

About FARSA

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,922,479-12,933,711 (from NCBI)

This gene has 10 transcripts (splice variants), 199 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 24.2), lymph node (RPKM 16.8) and 25 other tissues.

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression [provided by RefSeq, Jul 2008]

FARSA Products(1)

mRNA	Protein	Name
NM_004461.3	NP_004452.1	phenylalanine--tRNA ligase alpha subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phenylalanine-tRNA ligase activity	IDA IDA: Inferred from direct assay	20223217	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20223217	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in phenylalanyl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	20223217	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	20223217	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of phenylalanine-tRNA ligase complex	IDA IDA: Inferred from direct assay	20223217	GOA
part of phenylalanine-tRNA ligase complex	IPI IPI: Inferred from physical interaction	20223217	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FARSA Protein Structure

tRNA-synt_2d

0
100
200
300
400
508 a.a.

Protein Preferred Names

Protein Names

phenylalanine--tRNA ligase alpha subunit

pheRS

FARSA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	Anti Tag CoIP	33961781
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	Pull Down	20223217
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	Y2H Prey Pooling	32296183
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	GMS	20223217
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	X-Ray Diffraction	20223217
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	Y2H Array	32296183
Intra	FARSA	Q9Y285	FARSB	Homo sapiens	Q9NSD9	Anti Tag CoIP	28514442
Intra	FARSA	Q9Y285	COG4	Homo sapiens	Q9H9E3	Y2H Prey Pooling	32296183
Intra	FARSA	Q9Y285	COG4	Homo sapiens	Q9H9E3	Y2H Array	32296183
Intra	FARSA	Q9Y285	ECSIT	Homo sapiens	Q9BQ95	Pull Down	21163940
Intra	FARSA	Q9Y285	PDCD10	Homo sapiens	Q9BUL8	Y2H Prey Pooling	32296183
Intra	FARSA	Q9Y285	PDCD10	Homo sapiens	Q9BUL8	Y2H Array	32296183
Intra	FARSA	Q9Y285	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rajab Interstitial Lung Disease With Brain Calcifications 2

RILDBC2

Interstitial Lung Disease

Ild	Lung Diseases, Interstitial
Lung Diseases Interstitial	Interstitial Lung Diseases

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04749	FARSA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FARSA	RGD	RGD:1310314
Macaca mulatta	FARSA	VGNC	VGNC:72615
Felis catus	FARSA	VGNC	VGNC:62151
Mus musculus	FARSA	MGD	MGI:1913840
Bos taurus	FARSA	VGNC	VGNC:28867
Canis familiaris	FARSA	VGNC	VGNC:40733

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