VWCE - von Willebrand factor C and EGF domains Gene

Homo sapiens

Also known as VWC1; URG11

Gene ID: 220001 | Gene type: protein coding

About VWCE

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,258,286-61,295,316 (from NCBI)

This gene has 7 transcripts (splice variants), 114 orthologues and 19 paralogues. Broad expression in ovary (RPKM 4.8), liver (RPKM 2.1) and 15 other tissues.

Summary

Predicted to enable calcium ion binding activity. Involved in cellular response to virus. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

VWCE Products(1)

mRNA	Protein	Name
NM_152718.2	NP_689931.2	von Willebrand factor C and EGF domain-containing protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21653829	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to virus	IEP IEP: Inferred from expression pattern	16496348	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16496348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VWCE Protein Structure

EGF_CA

VWC

0
200
400
600
800
955 a.a.

Protein Preferred Names

Protein Names

von Willebrand factor C and EGF domain-containing protein

HBV X protein up-regulated gene 11 protein

Related Diseases

Diseases

Alias

Tarsal-Carpal Coalition Syndrome

TCC	Tarsal Carpal Coalition Syndrome
Nog-Related-Symphalangism Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15733	VWCE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VWCE	VGNC	VGNC:79617
Rattus norvegicus	VWCE	RGD	RGD:1309910
Felis catus	VWCE	VGNC	VGNC:66996
Bos taurus	VWCE	VGNC	VGNC:36859
Mus musculus	VWCE	MGD	MGI:1919018
Canis familiaris	VWCE	VGNC	VGNC:48327

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